Evidence map›Paper›PMID 38376248›Full record

ArticlemBio2024

Host E3 ubiquitin ligase ITCH mediates

Yifan Wang, L Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C Paredes-Santos, Shruthi Krishnamurthy, Bennett H Penn, Hao Wu, Jeroen P J Saeij

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Review
  3. A pooled image-based CRISPR screen identifies EAF1 as abioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yifan WangDepartment of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0001-9451-0041
L Robert HollingsworthDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Lamba Omar SangaréDepartment of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.
Tatiana C Paredes-SantosDepartment of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.
Shruthi KrishnamurthyDepartment of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.
Bennett H PennDepartment of Internal Medicine, Division of Infectious Diseases, UC Davis Health, Sacramento, California, USA.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Jeroen P J SaeijDepartment of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0003-0289-7109
University of California, Davis · USBoston Children's Hospital · USUniversity of California Davis Medical Center · USUniversity of Michigan · US

Funding

NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress SensingR01AI124491 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2025
$5.1M
Toxoplasma strain-specific modulation of mouse immune cellsR01AI080621 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2009 to 2018
$3.6M
Understanding How the Ubiquitin Ligase CBL Regulates Innate Immune ResponsesR01AI144149 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PENN, BENNETT · 2019 to 2023
$2.4M
Toxoplasma effector-mediated modulation of innate immune pathways in non-murine macrophagesR00AI163285 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, YIFAN · 2023 to 2024
$495k
Identification of the mechanism by which Toxoplasma activates the NLRP1 inflammasomeR21AI151081 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2020 to 2021
$432k
NIAID NIH HHS R00 AI163285NIAID NIH HHS R01 AI080621NIAID NIH HHS R01 AI124491NIAID NIH HHS R01 AI144149NIAID NIH HHS R21 AI151081
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ToxoplasmaAdenosine TriphosphatasesAnimalsHumansImmunity, InnateInflammasomesNLR ProteinsProtozoan ProteinsRatsRats, Inbred LewRepressor ProteinsUbiquitin-Protein LigasesAdenosine TriphosphatasesInflammasomesITCH protein, humanNLRP1 protein, humanNLR ProteinsProtozoan ProteinsRepressor ProteinsRNF213 protein, humanUbiquitin-Protein LigasesE3 ubiquitin ligaseeffector-triggered immunityIFNγNLRP1 inflammasomeToxoplasma gondii

Identifiers

PMID38376248
PMCPMC10936166
OpenAlexW4391954988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.