Evidence map›Paper›PMID 38376247›Full record

ArticleNeurogastroenterology and motility2024

Preliminary study on the dynamic positron emission tomography imaging with

Elisia Maalouf, Hala Khasawneh, Aashna Karbhari, Shefaa AlAsfoor, Margaret Breen-Lyles, Cheryl Bernard, Elizabeth Rajan, Gianrico Farrugia, Val Lowe, Ajit Goenka and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elisia MaaloufDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Hala KhasawnehDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Aashna KarbhariDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Shefaa AlAsfoorDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Margaret Breen-LylesDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Cheryl BernardDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Elizabeth RajanDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Val LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Ajit GoenkaDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-5092-0831
Mayo Clinic · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid BiopsyR01CA256969 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Collisson, Ajit Harishkumar Goenka · 2021 to 2026
$3.1M
Quantitative In Vivo 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 PET Imaging of Cancer-Associated Fibroblasts (CAFs) in Pancreatic Ductal Adenocarcinoma (PDA)R01CA272628 · NCI · MAYO CLINIC ROCHESTER · PI GOENKA, AJIT HARISHKUMAR · 2022 to 2025
$2.5M
NCI NIH HHS R01 CA256969NCI NIH HHS R01 CA272628NIDDK NIH HHS U24 DK076169NIH HHS
6 · The paper itself

Abstract

backgroundAnimal models and human data have suggested macrophage-driven immune dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO) upregulation has been suggested to indicate activated state of macrophages and ER176 is a high affinity third generation TSPO-specific radioligand. The aim of this study was to determine feasibility of dynamic

methodsTwelve patients, all females, were recruited (4 DG, 4 diabetics, and 4 healthy volunteers) for KEY

resultsAge was comparable among the three groups with a median of 53 years. The uptake was higher in pylorus in diabetics compared to DG and healthy (SUV CONCLUSIONS AND INFERENCES: Female diabetic gastroparesis patients did not demonstrate increased TSPO ligand

Indexed as

GastroparesisMacrophage ActivationAdultAgedCarbon RadioisotopesDiabetes ComplicationsFemaleHumansMiddle AgedPositron-Emission TomographyPositron Emission Tomography Computed TomographyCarbon Radioisotopesdiabetes mellitusgastroparesismacrophagesTSPO protein

Identifiers

PMID38376247
PMCPMC11042975
OpenAlexW4391971164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.