Evidence map›Paper›PMID 38376203›Full record

ArticleJournal of bacteriology2024

Identification of

Brianne R Zbylicki, Claire E Murphy, Jennifer A Petsche, Ute Müh, Horia A Dobrila, Theresa D Ho, Mikaela N Daum, Anthony G Pannullo, David S Weiss, Craig D Ellermeier

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Analysis of essential genes inJournal of bacteriology · 2025
    Article
  3. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Identification of a family of peptidoglycan transpeptidases reveals thatProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Brianne R ZbylickiDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-5795-9795
Claire E MurphyDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
Jennifer A PetscheInterdisciplinary Graduate Program in Molecular Medicine, University of Iowa, Iowa City, Iowa, USA.
Ute MühDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
Horia A DobrilaDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
Theresa D HoDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
Mikaela N DaumDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
Anthony G PannulloDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.
David S WeissDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-2217-0070
Craig D EllermeierDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-8953-5081
University of Iowa · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Identification of daptomycin resistance mechanisms in Clostridioides difficileR01AI087834 · NIAID · UNIVERSITY OF IOWA · PI ELLERMEIER, CRAIG D · 2011 to 2025
$5.6M
PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Regulation of the C. difficile cell envelope by Two-component systemsR21AI159411 · NIAID · UNIVERSITY OF IOWA · PI ELLERMEIER, CRAIG D · 2021 to 2022
$425k
NIAID NIH HHS R01 AI087834NIAID NIH HHS R21 AI159411NIAID NIH HHS T32 AI007511NIGMS NIH HHS T32 GM008365
6 · The paper itself

Abstract

Daptomycin is a cyclic lipopeptide antibiotic used to treat infections caused by some Gram-positive bacteria. Daptomycin disrupts synthesis of the peptidoglycan (PG) cell wall by inserting into the cytoplasmic membrane and binding multiple forms of the undecaprenyl carrier lipid required for PG synthesis. Membrane insertion requires phosphatidylglycerol, so studies of daptomycin can provide insight into assembly and maintenance of the cytoplasmic membrane. Here, we studied the effects of daptomycin on IMPORTANCE:

Indexed as

Clostridioides difficileDaptomycinAnti-Bacterial AgentsDiarrheaDrug Resistance, BacterialHumansPhosphatidylglycerolsAnti-Bacterial AgentsDaptomycinPhosphatidylglycerolsantibiotic resistancecell envelopesignal transductionstress response

Identifiers

PMID38376203
PMCPMC10955854
OpenAlexW4391972100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.