ReviewHuman brain mapping2024
What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?
Review in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Symptom Overlap and Neurobiological Similarities Between Posttraumatic Stress Disorder and Tinnitus.Human brain mapping · 2026Article
- Tinnitus and Reactions to Tinnitus: A Cross-Sectional Survey Across Different Tinnitus Durations.Audiology research · 2026Article
- EEG-Based Multifocal Tomographic Neurofeedback in Older Individuals With Chronic Tinnitus Does Not Lead to Persistent Electrophysiological Changes.Brain and behavior · 2026Article
- [Tinnitus-current developments : Overview and summary of current state of knowledge in 2024].HNO · 2025Review
- Topological properties of brain networks in patients with hemiplegic shoulder pain: a functional magnetic resonance imaging study.BMC neurology · 2025Article
- Breathing Rate as a Marker for Noise-Induced Stress in Guinea Pigs.Brain sciences · 2025Article
- Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach.BMC neuroscience · 2025Article
- Association between vertebral fractures and brain volume: insights from a community cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach.Scientific reports · 2025Article
- Neuroanatomical Insights: Convergence and Divergence of Tinnitus with Normal or Mild Hearing Loss.Biomedicines · 2025Article
- Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations.Frontiers in psychiatry · 2025Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by a number of studies. These structures are usually considered in the context of a "limbic system," a concept typically invoked to explain the emotional response to tinnitus. Despite this common framing, it is not apparent from current literature that this is necessarily the main functional role of these structures in persistent tinnitus. Here, we highlight a different role that encompasses their most commonly implicated functional position within the brain-that is, as a memory system. We consider tinnitus as an auditory object that is held in memory, which may be made persistent by associated activity from the hippocampus and parahippocampal gyrus. Evidence from animal and human studies implicating these structures in tinnitus is reviewed and used as an anchor for this hypothesis. We highlight the potential for the hippocampus/parahippocampal gyrus to facilitate maintenance of the memory of the tinnitus percept via communication with auditory cortex, rather than (or in addition to) mediating emotional responses to this percept.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.