Evidence map›Paper›PMID 38376096›Full record

ArticleMagnetic resonance in medicine2024

Cardiac DTI using short-axis PROPELLER: A feasibility study.

Mehdi Sadighi, Danielle Kara, Dingheng Mai, Khoi Nguyen, Shi Chen, Deborah Kwon, Christopher Nguyen

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Diffusion MRI of the Body: Beyond PGSE-EPI.Journal of magnetic resonance imaging : JMRI · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mehdi SadighiCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-4719-6229
Danielle KaraCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-8369-798X
Dingheng MaiCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Khoi NguyenCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Shi ChenCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Deborah KwonCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Christopher NguyenCardiovascular Innovation Research Center (CIRC), Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-1475-2329
Cleveland Clinic · US

Funding

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Stress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010NIBIB NIH HHS R01 EB033853NIH HHS R01 HL135242NIH HHS R01 HL151704NIH HHS R01HL159010
6 · The paper itself

Abstract

purposeWe aimed to develop a free-breathing (FB) cardiac DTI (cDTI) method based on short-axis PROPELLER (SAP) and M2 motion compensated spin-echo EPI (SAP-M2-EPI) to mitigate geometric distortion and eliminate aliasing in acquired diffusion-weighted (DW) images, particularly in patients with a higher body mass index (BMI). THEORY AND

methodsThe study involved 10 healthy volunteers whose BMI values fell into specific categories: BMI <25 (4 volunteers), 25< BMI <28 (5 volunteers), and BMI >30 (1 volunteer). We compared DTI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and helix angle transmurality (HAT), between SAP-M2-EPI and M2-ssEPI. To evaluate the performance of SAP-M2-EPI in reducing geometric distortions in the left ventricle (LV) compared to CINE and M2-ssEPI, we utilized the DICE similarity coefficient (DSC) and assessed misregistration area.

resultsIn all volunteers, SAP-M2-EPI yielded high-quality LV DWIs without aliasing, demonstrating significantly reduced geometric distortion (with an average DSC of 0.92 and average misregistration area of 90 mm

conclusionSAP-M2-EPI facilitates free-breathing cDTI of the entire LV, effectively eliminating aliasing and minimizing geometric distortion compared to M2-ssEPI. Furthermore, it preserves accurate quantification of myocardial microstructure.

Indexed as

Diffusion Magnetic Resonance ImagingDiffusion Tensor ImagingEcho-Planar ImagingFeasibility StudiesHeartHeart VentriclesHumanscardiac magnetic resonancediffusion tensor MRIdistortion correctionfree‐breathingmyocardiumPROPELLER MRI

Identifiers

PMID38376096
PMCPMC11102807
OpenAlexW4391956710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.