Evidence map›Paper›PMID 38376064›Full record

SynthesisJournal of the American Geriatrics Society2024

Nutrition interventions for body composition, physical function, cognition in hospitalized older adults: A systematic review of individuals 75 years and older.

Lisa Dowling, David H Lynch, Dakota Batchek, Chang Sun, Charlotte Mark-Wagstaff, Emily Jones, Micah Prochaska, Megan Huisingh-Sheetz, John A Batsis

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lisa DowlingThe Medical School, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8332-358X
David H LynchDivision of Geriatric Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-2512-9367
Dakota BatchekDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Chang SunDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Charlotte Mark-WagstaffThe Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Emily JonesHealth Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-4294-7564
Micah ProchaskaSection of Hospital Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Megan Huisingh-SheetzSection of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
John A BatsisDivision of Geriatric Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-0845-4416

Funding

Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner DyadsP50MD017349 · NIMHD · UNIVERSITY OF CHICAGO · PI HUANG, ELBERT S., LYNCH, ELIZABETH B · 2021 to 2025
$24.3M
Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults with Multiple Chronic Conditions: A Sequential, Multiple Assignment, Randomized TrialR01AG077163 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI John A. Batsis · 2023 to 2026
$2.9M
Mobile Health Obesity Wellness Intervention in Rural Older Adults_Res1K23AG051681 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATSIS, JOHN A. · 2016 to 2022
$1.1M
The Effect of Red Blood Cell Transfusion on Fatigue, Activity and Fatigability in Hospitalized Patients with AnemiaK23HL140132 · NHLBI · UNIVERSITY OF CHICAGO · PI PROCHASKA, MICAH THOMAS · 2018 to 2022
$736k
National Heart, Lung, and Blood Institute K23 Patient-Oriented Research Career Development Award NIH/NHLBI1K23HL140132NHLBI NIH HHS K23 HL140132NIA NIH HHS K23 AG051681NIA NIH HHS K23-AG-051681NIA NIH HHS R01 AG077163NIA NIH HHS R01-AG-077163NIMHD NIH HHS P50 MD017349
6 · The paper itself

Abstract

backgroundGlobally, the oldest old population is expected to triple by 2050. Hospitalization and malnutrition can result in progressive functional decline in older adults. Minimizing the impact of hospitalization on functional status in older adults has the potential to maintain independence, reduce health and social care costs, and maximize years in a healthy state. This study aimed to systematically review the literature to identify nutritional interventions that target physical function, body composition, and cognition in the older population (≥ 75 years).

methodsA systematic review was conducted to evaluate the efficacy of nutritional interventions on physical function, body composition, and cognition in adults aged ≥ 75 years or mean age ≥80 years. Searches of PubMed (National Institutes of Health, National Library of Medicine), Scopus (Elsevier), EMBASE (Elsevier), Cumulative Index to Nursing and Allied Health Literature (CINAHL) with Full Text (EBSCOhost), and PsycInfo (EBSCOhost) were conducted. Screening, data extraction, and quality assessment were performed in duplicate and independently (CRD42022355984; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=355984).

resultsOf 8311 citations identified, 2939 duplicates were excluded. From 5372 citations, 189 articles underwent full-text review leaving a total of 12 studies for inclusion. Interventions were food-based, protein-based, carbohydrate-based, personalized, or used parenteral nutrition. Ten studies monitored anthropometric or body composition changes with three showing maintenance or improvements in lean mass, body mass index, triceps skinfold, and mid-upper arm circumference compared with the control group. Six studies monitored physical function but only the largest study found a beneficial effect on activities of daily living. Two of three studies showed the beneficial effects of nutritional intervention on cognition.

conclusionThere are few, high-quality, nutrition-based interventions in older adults ≥75 years. Despite heterogeneity, our findings suggest that large, longer-term (>2 weeks) nutritional interventions have the potential to maintain body composition, physical function, and cognition in adults aged 75 years and older during hospitalization.

Indexed as

Body CompositionCognitionHospitalizationAgedAged, 80 and overFemaleHumansMaleMalnutritionNutritional Statusbody compositioncognitionhospitalnutritionnutritional supplementationoldest oldphysical function

Identifiers

PMID38376064
PMCPMC11226365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.