ArticleBrain and behavior2024
Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Trial
- A single-blind, randomized controlled trial of transcranial direct current stimulation in adults with obsessive-compulsive disorder as early augmentation.CNS spectrums · 2025Trial
- Altered anterior cingulate cortex functional connectivity in treatment-naïve obsessive-compulsive disorder: a resting-state fMRI study.Frontiers in psychiatry · 2026Article
- Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder.Brain and behavior · 2024Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive-compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD.
objectiveThe aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD.
methodsTwenty-eight medication-free patients with OCD and 20 healthy controls underwent resting-state functional magnetic resonance imaging. Seed-based FC and support vector machine (SVM) were used to analyze the imaging data.
resultsThe patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral anterior cingulate cortex (vACC), and left Crus II. No brain regions showed a remarkable difference in FC values in patients with OCD after 8 weeks of medication treatment. The reduced right DLPFC-right MTG and right DLPFC-right vACC connectivities were correlated with the clinical symptoms of OCD. SVM results showed that reduced right DLPFC-right MTG connectivity at rest could predict the therapeutic response to OCD medication.
conclusionsThe findings highlight the important role of the right DLPFC in the pathophysiological mechanism of OCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.