Evidence map›Paper›PMID 38376013›Full record

ArticleBrain and behavior2024

Association between fibrinogen-to-albumin ratio and functional prognosis of 3 months in patients with acute ischemic stroke after intravenous thrombolysis.

Xinxin Chen, Xiahong Xu, Ying Li, Feifeng Liu, Bei Zhang, Lian Zuo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinxin ChenDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.ORCID 0009-0002-4134-6887
Xiahong XuDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
Ying LiDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
Feifeng LiuDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
Bei ZhangDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
Lian ZuoDepartment of Neurology, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
Shanghai East Hospital · CN

Funding

Clinical Plateau Discipline Construction Project of Shanghai Pudong New Area Health Committee PWYgy2021-05National Natural Science Foundation of China 82271456Program for Young Excellent Talents in Pudong New Area Health System, Shanghai, China PWRq2020-10Talents Training Program of Shanghai East Hospital 2019xrrcjh06
6 · The paper itself

Abstract

backgroundThe presence of high fibrinogen and low albumin levels in serum is associated with a negative prognosis in acute ischemic stroke (AIS). Fibrinogen-to-albumin ratio (FAR), a new inflammatory biomarker, may provide better prognostic insights in patients with AIS than separate evaluation of fibrinogen or albumin. The objective of this investigation is to examine the correlation between FAR and 3-month functional prognosis after intravenous thrombolysis (IVT) in AIS patients.

methodsThe retrospective study recruited AIS patients who received IVT from June 2014 to December 2021. The 3-month functional prognosis was assessed using the Modified Rankin Scale (mRS). A mRS score of ≤2 indicated a good outcome, whereas a mRS score of >2 suggested a poor outcome.

resultsA total of 591 AIS patients who underwent IVT were included and 147 patients (24.9 %) had a poor outcome. Among the 102 pairs of patients after propensity score matching, there was a significant association between FAR and 3-month prognosis (adjusted OR, 1.19; 95% CI, 1.03-1.38; p = .020). The optimal FAR cutoff value was found to be 7.57, and even after stratifying patients based on this value, we still observed a significant correlation between high FAR level and poor outcome (adjusted OR, 2.08; 95% CI, 1.28-3.40; p = .003).

conclusionsFAR may serve as a prospective biomarker of predicting 3-month prognosis in AIS patients after IVT.

Indexed as

Brain IschemiaIschemic StrokeStrokeAlbuminsBiomarkersFibrinogenFibrinolytic AgentsHumansPrognosisRetrospective StudiesThrombolytic TherapyTreatment OutcomeAlbuminsBiomarkersFibrinogenFibrinolytic Agentsacute ischemic strokefibrinogen-to-albumin ratiointravenous thrombolysisprognosis

Identifiers

PMID38376013
PMCPMC10757894
OpenAlexW4390474422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.