ArticleJournal of clinical hypertension (Greenwich, Conn.)2024
Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross-sectional study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Assessment of Blood-Count-Derived Biomarkers, Homocysteine Levels, MTHFR Mutation, and Clinical Manifestations in Severe Peripheral Artery Disease.Biomedicines · 2026Article
- Homocysteine levels alter the TyG index-CKD link in Chinese hypertensive patients.BMC nephrology · 2025Observational
- Impact of remnant cholesterol on arterial stiffness and mediating role of systolic blood pressure in chinese hypertensive adults.BMC public health · 2025Article
- Commentary on "Association of Plasma Homocysteine With Peripheral Arterial Disease in Hypertensive Adults: A Cross-Sectional Study".Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Increased plasma homocysteine (Hcy) has been identified as one of the important risk factors for cardiovascular disease. However, the association between plasma Hcy and peripheral artery disease (PAD) is still controversial. This study aimed to investigate the association between plasma Hcy and PAD and the potential modifier factors in Chinese hypertensive adults. A total of 25 300 hypertensive patients aged 18 years or older were included in the analysis in this cross-sectional study. The outcome was PAD, which defined as an ankle-brachial index ≤0.90 in either limb. Multiple logistic regression was used to analyze the relationship between plasma Hcy and PAD. The median plasma Hcy was 14.00 (interquartile range: 11.60-17.80) μmol/L. There was a significant positive association between plasma Hcy and PAD (per SD increment; OR: 1.13; 95% CI: 1.06-1.19). Patients in the upper plasma Hcy tertile (≥16.16 μmol/L) were associated with a 53% increased risk of PAD compared with patients in the lower tertile (<12.33 μmol/L) after adjustment for multiple potential confounders. Subgroup analyses showed the association between Hcy and PAD was robust among various strata. Among Chinese adults with hypertension, plasma Hcy is an independent risk factor for PAD. This finding may improve the risk stratification of PAD.
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