ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
General cognitive ability in high school, attained education, occupational complexity, and dementia risk.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- How Verbal Intelligence Predicts Emotional Stability: The Moderating Role of Empathy.Journal of Intelligence · 2026Article
- Moderating effects of educational inequality on education polygenic scores, attained education and dementia-risk relationships.SSM - population health · 2026Article
- Development and validation of MethylCog, a blood DNA methylation proxy for cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Occupational social interaction is associated with reduced dementia risk: The Trøndelag Health Study (HUNT).Psychology and aging · 2026Article
- Review
- Cross-sectional and longitudinal associations between anxiety and acoustic-prosodic markers in adolescents.Psychological medicine · 2025Article
- Early cognitive ability and dementia risk: Response to Chen and colleagues.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A lifespan perspective on cognitive reserve and risk for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- General cognitive ability in high school, attained education, occupational complexity, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionWe address the extent to which adolescent cognition predicts dementia risk in later life, mediated by educational attainment and occupational complexity.
methodsUsing data from Project Talent Aging Study (PTAS), we fitted two structural equation models to test whether adolescent cognition predicts cognitive impairment (CI) and Ascertain Dementia 8 (AD8) status simultaneously (N
resultsEducation partially mediated the effect of adolescent cognition on CI in the cognitive assessment aample and AD8 in the questionnaire sample (Ps < 0.001). Within twin pairs, differences in adolescent cognition were small, but intrapair differences in education predicted CI status. DISCUSSION: Adolescent cognition predicted dementia risk 60 years later, partially mediated through education. Educational attainment, but not occupational complexity, contributes to CI risk beyond its role as a mediator of adolescent cognition, further supported by the co-twin analyses. HIGHLIGHTS: Project Talent Aging Study follows enrollees from high school for nearly 60 years. General cognitive ability in high school predicts later-life cognitive impairment. Low education is a risk partially due to its association with cognitive ability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.