ArticlePaediatric and perinatal epidemiology2024
Pregnancy-associated mortality due to cardiovascular disease: Impact of hypertensive disorders of pregnancy.
Article in Paediatric and perinatal epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Hypertension Management in Pregnancy and Postpartum.Journal of the American Society of Nephrology : JASN · 2026Review
- Impacts of Paid Family Leave on Perinatal Health: A Nationwide Quasi-Experimental Study.Pediatrics · 2026Article
- The Emerging Role of Interferon-Stimulated Gene 15 (ISG15) in Pregnancy-Related Disorders.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Evaluation of Home Blood Pressure Monitoring for Patients with Hypertensive Disorders of Pregnancy: A Rapid Review.Healthcare (Basel, Switzerland) · 2026Review
- Peripartum Telehealth Care Utilization During the COVID-19 Pandemic, by Hypertension Status, PCORnet®, 2018 to 2023.Medical care · 2026Article
- Peripartum dapagliflozin improves late-life maternal cardiovascular outcomes in a murine model of superimposed preeclampsia.American journal of obstetrics and gynecology · 2025Article
- Hypertensive Disorders of Pregnancy: Reaching the Rural Population After Delivery.Current hypertension reports · 2025Review
- Current Evidence of Maternal Infection With Chlamydia trachomatis and Preeclampsia Risk.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Hospitalization for cardiovascular disease in the year after delivery of twin pregnancies.European heart journal · 2025Article
- Global, regional, and national burden and trends of intracerebral hemorrhage among adolescents and young adults aged 15-39 years from 1990 to 2021: a comprehensive trend analysis based on the global burden of disease study 2021.Frontiers in neurology · 2025Article
- Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Obstetrical complications and chronic health along the life course: What we know, what we don't, and where we go from here?Paediatric and perinatal epidemiology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundReported rates of maternal mortality in the United States have been staggeringly high and increasing, and cardiovascular disease (CVD) is a chief contributor to such deaths. However, the impact of hypertensive disorders of pregnancy (HDP) on the short-term risk of cardiovascular death is not well understood.
objectivesTo evaluate the association between HDP (chronic hypertension, gestational hypertension, preeclampsia, eclampsia, and superimposed preeclampsia) and pregnancy-associated mortality rates (PMR) from all causes, CVD-related causes both at delivery and within 1 year following delivery.
methodsWe used the Nationwide Readmissions Database (2010-2018) to examine PMRs for females 15-54 years old. International Classification of Disease 9 and 10 diagnosis codes were used to identify pregnancy-associated deaths due to HDP and CVD. Discrete-time Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality at delivery (0 days) and at <30, <60, <90, <180, and <365 days after delivery in relation to HDP.
resultsOf 33,417,736 hospital deliveries, the rate of HDP was 11.0% (n = 3,688,967), and the PMR from CVD was 6.4 per 100,000 delivery hospitalisations (n = 2141). Compared with normotensive patients, HRs for CVD-related PMRs increased with HDP severity, reaching over 58-fold for eclampsia patients. HRs were higher for stroke-related (1.2 to 170.9) than heart disease (HD)-related (0.99 to 39.8) mortality across all HDPs. Except for gestational hypertension, the increased risks of CVD mortality were evident at delivery and persisted 1 year postpartum for all HDPs.
conclusionsHDPs are strong risk factors for pregnancy-associated mortality due to CVD at delivery and within 1 year postpartum; the risks are stronger for stroke than HD-related PMR. While absolute PMRs are low, this study supports the importance of extending postpartum care beyond the traditional 42-day postpartum visit for people whose pregnancies are complicated by hypertension.
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