Evidence map›Paper›PMID 38375831›Full record

ArticleGut microbes

Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice.

Melanie A Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani, Jessica Miranda Bustamante, Rosalinda Moreno, Michael L Goodson, Allison Ehrlich, Ameer Y Taha, Pamela J Lein and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  10. Relieving Effect ofAntioxidants (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Melanie A ReuterDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Madelynn TuckerDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Zara MarforiDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Rahaf ShishaniDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Jessica Miranda BustamanteDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Rosalinda MorenoDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
Michael L GoodsonDepartment of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California - Davis, Davis, CA, USA.
Allison EhrlichDepartment of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California - Davis, Davis, CA, USA.
Ameer Y TahaDepartment of Food Science and Technology, University of California - Davis, Davis, CA, USA.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California - Davis, Davis, CA, USA.
Nikhil JoshiBioinformatics Core, UC Davis Genome Center, University of California - Davis, Davis, CA, USA.
Ilana BritoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Blythe Durbin-JohnsonBioinformatics Core, UC Davis Genome Center, University of California - Davis, Davis, CA, USA.
Renu NandakumarBiomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA.
Bethany P CummingsDepartment of Surgery, Center for Alimentary and Metabolic Sciences, School of Medicine, University of California - Davis, Sacramento, CA, USA.
University of California, Davis · USColumbia University Irving Medical Center · USCornell University · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Initiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2M
Mapping bile acid metabolism across the gut microbiome in response to dietary fiberR21AT010956 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CUMMINGS, BETHANY PAIGE · 2021 to 2022
$572k
NCATS NIH HHS UL1 TR001873NCCIH NIH HHS R21 AT010956NIEHS NIH HHS T32 ES007059NIGMS NIH HHS T32 GM135741
6 · The paper itself

Abstract

Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, which can differentially regulate host health via signaling based on their varying affinity for BA receptors. Despite the importance of secondary BAs in host health, the regulation of 7-α-dehydroxylation and the role of diet in modulating this process is incompletely defined. Understanding this process could lead to dietary guidelines that beneficially shift BA metabolism. Dietary fiber regulates gut microbial composition and metabolite production. We tested the hypothesis that feeding mice a diet rich in a fermentable dietary fiber, resistant starch (RS), would alter gut bacterial BA metabolism. Male and female wild-type mice were fed a diet supplemented with RS or an isocaloric control diet (IC). Metabolic parameters were similar between groups. RS supplementation increased gut luminal deoxycholic acid (DCA) abundance. However, gut luminal cholic acid (CA) abundance, the substrate for 7-α-dehydroxylation in DCA production, was unaltered by RS. Further, RS supplementation did not change the mRNA expression of hepatic BA producing enzymes or ileal BA transporters. Metagenomic assessment of gut bacterial composition revealed no change in the relative abundance of bacteria known to perform 7-α-dehydroxylation.

Indexed as

Gastrointestinal MicrobiomeResistant StarchAnimalsBacteriaBile Acids and SaltsDeoxycholic AcidDietary SupplementsFemaleMaleMiceBile Acids and SaltsDeoxycholic AcidResistant Starch7-α-dehydroxylationbile acidDCAgut microbiomemetagenomicsResistant starch

Identifiers

PMID38375831
PMCPMC10880513
OpenAlexW4391959752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.