Evidence map›Paper›PMID 38375612›Full record

ArticleThe Journal of comparative neurology2024

Efficacy and specificity of melanopsin reporters for retinal ganglion cells.

Ryan Maloney, Lauren Quattrochi, James Yoon, Rachel Souza, David Berson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  7. Flp-recombinase mouse line for genetic manipulation of ipRGCs.bioRxiv : the preprint server for biology · 2024
    Article
  8. A newbioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryan MaloneyDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
Lauren QuattrochiDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
James YoonDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
Rachel SouzaDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
David BersonDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
Brown University · USHarvard University · US

Funding

STRUCTURE AND FUNCTION OF MAMMALIAN GANGLION CELLSR01EY012793 · NEI · BROWN UNIVERSITY · PI BERSON, DAVID M. · 2000 to 2022
$9.3M
NEI NIH HHS R01 EY012793NIH HHS EY012793
6 · The paper itself

Abstract

Intrinsically photosensitive retinal ganglion cells (ipRGCs) are specialized retinal output neurons that mediate behavioral, neuroendocrine, and developmental responses to environmental light. There are diverse molecular strategies for marking ipRGCs, especially in mice, making them among the best characterized retinal ganglion cells (RGCs). With the development of more sensitive reporters, new subtypes of ipRGCs have emerged. We therefore tested high-sensitivity reporter systems to see whether we could reveal yet more. Substantial confusion remains about which of the available methods, if any, label all and only ipRGCs. Here, we compared many different methods for labeling of ipRGCs, including anti-melanopsin immunofluorescence, Opn4-GFP BAC transgenic mice, and Opn4

Indexed as

Retinal Ganglion CellsRod OpsinsAnimalsLightMelanopsinMiceMice, TransgenicMelanopsinRod Opsins

Identifiers

PMID38375612
PMCPMC11000424
OpenAlexW4391964534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.