Evidence map›Paper›PMID 38375577›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Developmental changes in lung function of mice are independent of sex as a biological variable.

Thomas Bärnthaler, Abhay B Ramachandra, Sadè Ebanks, Nicole Guerrera, Lokesh Sharma, Charles S Dela Cruz, Jay D Humphrey, Edward P Manning

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  8. Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas BärnthalerDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Abhay B RamachandraDepartment of Biomedical Engineering,Yale University, New Haven, Connecticut, United States.ORCID 0000-0001-6275-501X
Sadè EbanksSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University, New Haven, Connecticut, United States.
Nicole GuerreraDepartment of Medicine (Cardiovascular Medicine), Yale Translational Research Imaging Center, Yale University, New Haven, Connecticut, United States.
Lokesh SharmaSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University, New Haven, Connecticut, United States.ORCID 0000-0003-3040-9029
Charles S Dela CruzSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University, New Haven, Connecticut, United States.
Jay D HumphreyDepartment of Biomedical Engineering,Yale University, New Haven, Connecticut, United States.ORCID 0000-0003-1011-2025
Edward P ManningSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University, New Haven, Connecticut, United States.ORCID 0000-0002-4430-8168

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Age-related Changes in the Pulmonary ArteryR03AG074063 · NIA · YALE UNIVERSITY · PI MANNING, EDWARD P · 2022 to 2023
$335k
Additional Ventures | Single Ventricle Research FundApart-Mint FellowshipHHS | NIH | National Institute on Aging (NIA) P30AG021342HHS | NIH | National Institute on Aging (NIA) R03AG074063NCATS NIH HHS UL1 TR001863Schrodinger FellowshipVA | VISN 1 CDA
6 · The paper itself

Abstract

Pulmonary function testing (PFT) in mice includes biomechanical assessment of lung function relevant to physiology in health and its alteration in disease, hence, it is frequently used in preclinical modeling of human lung pathologies. Despite numerous reports of PFT in mice of various ages, there is a lack of reference data for developing mice collected using consistent methods. Therefore, we profiled PFTs in male and female C57BL/6J mice from 2 to 23 wk of age, providing reference values for age- and sex-dependent changes in mouse lung biomechanics during development and young adulthood. Although males and females have similar weights at birth, females weigh significantly less than males after 5 wk of age (

Indexed as

LungMice, Inbred C57BLRespiratory Function TestsAgingAnimalsBody WeightFemaleMaleMiceSex CharacteristicsSex Factorsallometrydevelopmentlung functionsex as a biological variable

Identifiers

PMID38375577
PMCPMC11380952

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.