Evidence map›Paper›PMID 38375425›Full record

ArticleERJ open research2024

Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis.

Beatriz Guillen-Guio, Megan L Paynton, Richard J Allen, Daniel P W Chin, Lauren J Donoghue, Amy Stockwell, Olivia C Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan and 36 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Genomic and Serological Rheumatoid Arthritis Biomarkers,Annals of the American Thoracic Society · 2025
    Article
  4. Review
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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 4 countries.

Beatriz Guillen-GuioDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Megan L PayntonDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Richard J AllenDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Daniel P W ChinDepartment of Population Health Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-7349-895X
Lauren J DonoghueGenentech, San Francisco, CA, USA.
Amy StockwellGenentech, San Francisco, CA, USA.
Olivia C LeavyDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Tamara Hernandez-BeeftinkDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Carl ReynoldsNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7415-258X
Paul CullinanNational Heart & Lung Institute, Imperial College London, London, UK.
Fernando MartinezDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Helen L BoothUniversity College Hospital, University College London, London, UK.
William A FahyGlaxoSmithKline, London, UK.
Ian P HallSchool of Medicine, University of Nottingham, Nottingham, UK.
Simon P HartHull York Medical School, University of Hull, Hull, UK.ORCID https://orcid.org/0000-0003-4606-9559
Mike R HillMRC Population Health Unit, University of Oxford, Oxford, UK.
Nik HiraniCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Richard B HubbardSchool of Medicine, University of Nottingham, Nottingham, UK.
Robin J McAnultyDivision of Medicine, University College London, London, UK.
Ann B MillarBristol Medical School, University of Bristol, Bristol, UK.
Vidya NavaratnamDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Eunice OballaGlaxoSmithKline, London, UK.
Helen ParfreyRoyal Papworth Hospital NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0002-4515-5634
Gauri SainiSchool of Medicine, University of Nottingham, Nottingham, UK.
Ian SayersCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Martin D TobinDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Moira K B WhyteCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Ayodeji AdegunsoyeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Naftali KaminskiPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-5917-4601
Shwu-Fan MaDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Mary E StrekDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Yingze ZhangDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-6947-2901
Tasha E FingerlinDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.
Maria Molina-MolinaServei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain.
Margaret NeighborsGenentech, San Francisco, CA, USA.
X Rebecca ShengGenentech, San Francisco, CA, USA.
Justin M OldhamDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Toby M MaherNational Heart and Lung Institute, Imperial College London, London, UK.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-1301-8800
Carlos FloresCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Imre NothDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
David A SchwartzDepartment of Medicine, University of Colorado, Anscuhtz, CO, USA.
Brian L YaspanGenentech, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-3787-2510
R Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, UK.
Louise V WainDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Edward J HolloxDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-0115-2298
University of Leicester · GBUniversity of Nottingham · GBImperial College London · GBCentre for Inflammation Research · GBGlaxoSmithKline (United Kingdom) · GBInstituto de Salud Carlos III · ESUniversity of Illinois Chicago · USUniversity of Virginia · USCornell University · USGuy's and St Thomas' NHS Foundation Trust · GBNational Jewish Health · USNottingham University Hospitals NHS Trust · GBPapworth Hospital NHS Foundation Trust · GBUniversity College Hospital · GBUniversity College London · GBUniversity of Bristol · GBUniversity of Colorado Anschutz Medical Campus · USUniversity of Hull · GBUniversity of Michigan · USUniversity of Oxford · GB

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Targeting early events in MUC5B-driven lung injury and fibrosisP01HL162607 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David Albert Schwartz · 2023 to 2026
$12.4M
Preclinical Pulmonary Fibrosis, an opportune rare disease cohortUH3HL151865 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2022 to 2025
$4.3M
Proteomic Profiling of Idiopathic Pulmonary Fibrosis Progression TrajectoryR01HL169166 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin M Oldham · 2023 to 2026
$2.7M
Elucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary FibrosisK23HL138190 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, JUSTIN M · 2017 to 2021
$914k
Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic ClustersK23HL146942 · NHLBI · UNIVERSITY OF CHICAGO · PI ADEGUNSOYE, AYODEJI · 2020 to 2024
$810k
Derivation and validation of a clinical-molecular signature to predict fibrotic progression and treatment response in patients with autoimmune interstitial lung diseaseR56HL158935 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OLDHAM, JUSTIN M · 2021 to 2021
$400k
lncRNAs, Linking Genetic Susceptibility to Molecular Phenotype in IPFI01BX005295 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI David Albert Schwartz · 2022 to 2026
–
BLRD VA I01 BX005295HSRD VA CDA 13-017Medical Research Council MC_PC_19004NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL138190NHLBI NIH HHS K23 HL146942NHLBI NIH HHS P01 HL162607NHLBI NIH HHS R01 HL169166NHLBI NIH HHS R56 HL158935NHLBI NIH HHS UH3 HL151865Wellcome Trust 201291/Z/16/Z
6 · The paper itself

Abstract

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior association of the Methods: We performed a meta-analysis of associations of the HLA region with IPF risk in individuals of European ancestry from seven independent case-control studies of IPF (comprising 5159 cases and 27 459 controls, including a prior study of fibrotic interstitial pneumonia). Single nucleotide polymorphisms, classical HLA alleles and amino acids were analysed and signals meeting a region-wide association threshold of p<4.5×10 Results: The meta-analysis of all seven studies identified four significant independent single nucleotide polymorphisms associated with IPF risk. However, none met the posterior probability for replication criterion. The Conclusion: Variation in the HLA region was not consistently associated with risk in studies of IPF. However, this does not preclude the possibility that other genomic regions linked to the immune response may be involved in the aetiology of IPF.

Identifiers

PMID38375425
PMCPMC10875457
OpenAlexW4390049167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.