Evidence map›Paper›PMID 38375212›Full record

ArticleAdvances in hematology2024

An Approach to the Investigation of Thrombocytosis: Differentiating between Essential Thrombocythemia and Secondary Thrombocytosis.

Ala Almanaseer, Benjamin Chin-Yee, Jenny Ho, Alejandro Lazo-Langner, Laila Schenkel, Pratibha Bhai, Bekim Sadikovic, Ian H Chin-Yee, Cyrus C Hsia

Abstract read
In one paragraph

Article in Advances in hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Single-cell RNA sequencing of platelets: challenges and potential.Journal of thrombosis and thrombolysis · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ala AlmanaseerDepartment of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0009-0008-4243-4284
Benjamin Chin-YeeDivision of Hematology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-0737-3603
Jenny HoDivision of Hematology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0009-0002-8969-2893
Alejandro Lazo-LangnerDivision of Hematology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-6869-8431
Laila SchenkelMolecular Diagnostic Division, Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-4980-7484
Pratibha BhaiMolecular Diagnostic Division, Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-4934-757X
Bekim SadikovicDepartment of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-6363-0016
Ian H Chin-YeeDivision of Hematology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-8719-7250
Cyrus C HsiaDivision of Hematology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-4287-6708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thrombocytosis is a common reason for referral to Hematology. Differentiating between secondary causes of thrombocytosis and essential thrombocythemia (ET) is often clinically challenging. A practical diagnostic approach to identify secondary thrombocytosis could reduce overinvestigation such as next generation sequencing (NGS) panel. Methods and Results: All adult patients with thrombocytosis (≥450 × 10 Conclusion: A practical approach to investigating patients with persistent thrombocytosis based on clinical characteristics such as active malignancy, chronic inflammatory disease, splenectomy, and iron deficiency may assist in accurately identifying patients more likely to have secondary causes of thrombocytosis and reduce overinvestigation, particularly costly molecular testing.

Identifiers

PMID38375212
PMCPMC10876298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.