Evidence map›Paper›PMID 38374874›Full record

ArticleInternational journal of pharmaceutics: X2024

Design and validation of a custom-made system to measure transepithelial electrical impedance in human corneas preserved in active storage machine.

Marielle Mentek, Benjamin Peyret, Siwar Zouari, Sébastien Urbaniak, Jean-Marie Papillon, Emmanuel Crouzet, Chantal Perrache, Sophie Hodin, Xavier Delavenne, Zhiguo He and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marielle MentekLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Benjamin PeyretLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Siwar ZouariLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Sébastien UrbaniakLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Jean-Marie PapillonLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Emmanuel CrouzetLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Chantal PerracheLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Sophie HodinINSERM U1059, Dysfonction Vasculaire et Hémostase, Université Jean Monnet, 10 rue de la Marandière, Campus Santé Innovations, Saint-Priest-en-Jarez, Saint-Etienne, France.
Xavier DelavenneINSERM U1059, Dysfonction Vasculaire et Hémostase, Université Jean Monnet, 10 rue de la Marandière, Campus Santé Innovations, Saint-Priest-en-Jarez, Saint-Etienne, France.
Zhiguo HeLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Philippe GainLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.
Gilles ThuretLaboratory of Biology, Engineering and Imaging for Ophthalmology (BiiO), EA2521, Faculté de Médecine, Université de Jean Monnet, 10 rue de la Marandière, 42270 Saint-Etienne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal epithelial barrier represents one of the major limitations to ocular drug delivery and can be explored non-invasively through the evaluation of its electrical properties. Human corneas stored in active storage machine (ASM) could represent an interesting physiological model to explore transcorneal drug penetration. We designed a new system adapted to human corneas preserved in ASM to explore corneal epithelial barrier function ex-vivo. A bipolar set-up including Ag/AgCl electrodes adaptors to fit the corneal ASM and a dedicated software was designed and tested on freshly excised porcine corneas (

Indexed as

Benzalkonium chlorideCorneal active storage machineCorneal epithelial barrierCorneal impedance

Identifiers

PMID38374874
PMCPMC10875219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.