ArticleThe journal of prevention of Alzheimer's disease2024
Exploring the Association between Amyloid-β and Memory Markers for Alzheimer's Disease in Cognitively Unimpaired Older Adults.
Article in The journal of prevention of Alzheimer's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- NavegApp, a serious game for assessing spatial cognition: Diagnostic accuracy in preclinical and prodromal Alzheimer's disease.PLOS digital health · 2026Article
- A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer's disease.Scientific reports · 2026Article
- Aberrant Brain Entropy in Alzheimer's Disease: Evidence From a Resting-State fMRI Study.Brain and behavior · 2026Article
- Short-term memory conjunctive binding in subjective cognitive decline: A PET biomarker-based study.Journal of neurology · 2026Article
- Optimizing the Color Shapes Task for Ambulatory Assessment and Drift Diffusion Modeling: A Factorial Experiment.JMIR formative research · 2025Article
- Eye movements powered by artificial intelligence identify asymptomatic carriers of familial Alzheimer's disease.Brain communications · 2025Article
- Article
- FAST functional connectivity implicates P300 connectivity in working memory deficits in Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMemory tests vary in their sensitivity for detection of pre-symptomatic Alzheimer's disease (AD). The Visual Short-Term Memory Binding Test (VSTMBT) identifies AD-related performance deficits in older adults who are otherwise cognitively unimpaired.
objectiveWe investigated the association of this psychometric measure with brain amyloidosis and atrophy.
designCross-sectional mixed and correlational.
settingCognitive Reserve Study from Columbia University.
participantsa sample of 39 cognitively unimpaired older adults (Age: M=65.3, SD=3.07) was obtained from the above study. MEASUREMENTS: Extensive neuropsychological and neuroimaging (MRI and amyloid-β PET) assessments were carried out.
resultsPerformance on the VSTMBT allowed us to split the sample into Low Binding Cost (LBC, N=21) and High Binding Cost (HBC, N=18). Groups were matched according to age [p=0.702], years of education [0.071], and sex [p=0.291]. HBC's performance was comparable to that seen in symptomatic AD. Groups only differed in their amyloid-β deposition on PET in regions of the right ventral stream linked to visual cognition and affected early in AD pathogenesis (lateral-occipital cortex, p = 0.008; fusiform gyrus, p = 0.017; and entorhinal cortex, p = 0.046). Other regions known to be linked to low-level visual integration function also revealed increased amyloid-β deposition in HBC.
conclusionsVSTMB deficits are associated with neuropathogenesis (i.e., amyloid-β deposition) in the earliest affected regions in pre-symptomatic AD. The VSTMB test holds potential for the identification of cognitively unimpaired older adults with very early AD pathogenesis and may thus be a useful tool for early intervention trials or other forms of clinical research.
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