Evidence map›Paper›PMID 38374568›Full record

Trial reportJournal of pediatric gastroenterology and nutrition2024

Faster discharge with lactated ringers than normal saline in first 72 h of acute pancreatitis: A multicenter randomized trial.

Peter R Farrell, Angelica W DesPain, Peter Farmer, Leslie M Farrell, Bryan Greenfield, Michael E Rogers, Lindsey Hornung, Esther Kim, Ryan Pearman, Beemnet Neway and 5 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pediatric gastroenterology and nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03242473 (Mitigating the Inflammatory Response in Acute Pancreatitis With Appropriate Fluid Management; A Randomized Clinical Control Trial Comparing the Effects of Lactated Ringers and Normal Saline), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03242473 nacompletednot on this map

Mitigating the Inflammatory Response in Acute Pancreatitis With Appropriate Fluid Management; A Randomized Clinical Control Trial Comparing the Effects of Lactated Ringers and Normal Saline

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2014 to 2020Enrolled79ConditionsPancreatitisArmsFluid Management
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peter R FarrellDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-0559-3779
Angelica W DesPainDivision of Emergency Medicine, The Children's Hospital of San Antonio, San Antonio, Texas, USA.
Peter FarmerDivision of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Leslie M FarrellDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Bryan GreenfieldDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Michael E RogersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Lindsey HornungDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Esther KimDivision of Critical Care Medicine, Children's National Health System, Washington, District of Columbia, USA.
Ryan PearmanAlabama College of Osteopathic Medicine, Dothan, Alabama, USA.
Beemnet NewayDepartment of Pediatrics, NewYork Presbyterian-Weill Cornell Medical Center, New York City, New York, USA.
Tyler ThompsonDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
James E HeubiDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Sona SehgalDivision of Gastroenterology, Hepatology and Nutrition, Children's National Health System, Washington, District of Columbia, USA.
Rana AmouryDepartment of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Maisam Abu-El-HaijaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Kathryn Ann Wikenheiser-Brokamp · 2007 to 2026
$24.4M
PEDIATRIC GASTROENTEROLOGY AND NUTRITION TRAINING GRANTT32DK007727 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Phillip P Minar · 1995 to 2026
$11.3M
Predicting Severity and Improving the Outcomes of Pediatric PancreatitisK23DK118190 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ABU-EL-HAIJA, MAISAM · 2018 to 2022
$947k
NIDDK NIH HHS K23 DK118190NIDDK NIH HHS K23DK118190NIDDK NIH HHS P30 DK078392NIDDK NIH HHS T32 DK007727NIH HHS 5UL1TR001425
6 · The paper itself

Abstract

objectivesData driven strategies for acute pancreatitis (AP) in pediatrics are limited; adult data suggests lactated ringers (LR) compared to normal saline (NS) resulted in favorable outcomes, but has not been studied in pediatrics. Our objective was to evaluate the efficacy of LR during the first 48 h of an AP episode compared with NS. STUDY

designA multisite randomized controlled clinical trial, from 2015 to 2020 (Clinical Trials.gov NCT03242473). Patients were randomized to exclusively LR or NS for the first 48 h. Primary outcomes were serial C-reactive protein (CRP) values. Secondary outcomes included other lab values, time to feeds, length of stay (LOS), systemic inflammatory response syndrome (SIRS) development, and progression to severe AP (SAP).

resultsWe studied 76 patients (38 LR, 38 NS). CRP at 24 and 48 h were not significantly different between LR or NS group. Additionally, there were no differences in trends of BUN, amylase, lipase, SIRS status, or SAP development between the LR and NS group at 24 and 48 h. A higher proportion of LR patients (32%, 12/38) were discharged before 48 h compared to NS (13%, 5/38). The LR group had a significantly higher rate of discharge within the first 72 h compared to the NS group (p = 0.02).

conclusionThe use of LR was associated with a faster rate of discharge during the intervention period and in the first 72 h, but no other differences compared to NS. This reduction in length of hospitalization has significant implications for patients and healthcare costs.

Indexed as

Fluid TherapyPancreatitisPatient DischargeAcute DiseaseChildHumansRinger's LactateSaline SolutionSystemic Inflammatory Response SyndromeRinger's LactateSaline Solutionacute pancreatitislactated ringersnormal salinepediatrics

Identifiers

PMID38374568
PMCPMC10883603

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.