Evidence map›Paper›PMID 38374428›Full record

ArticleScientific reports2024

Prefrontal cortex structural and developmental associations with callous-unemotional traits and aggression.

Nathan Hostetler, Tamara P Tavares, Mary B Ritchie, Lindsay D Oliver, Vanessa V Chen, Steven Greening, Elizabeth C Finger, Derek G V Mitchell

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nathan HostetlerBrain and Mind Institute, Western Interdisciplinary Research Building, Room 3190, Western University, London, ON, N6A 5B7, Canada.
Tamara P TavaresBrain and Mind Institute, Western Interdisciplinary Research Building, Room 3190, Western University, London, ON, N6A 5B7, Canada.
Mary B RitchieBrain and Mind Institute, Western Interdisciplinary Research Building, Room 3190, Western University, London, ON, N6A 5B7, Canada.
Lindsay D OliverCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Vanessa V ChenBrain and Mind Institute, Western Interdisciplinary Research Building, Room 3190, Western University, London, ON, N6A 5B7, Canada.
Steven GreeningDepartment of Psychology, University of Manitoba, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0003-4578-4139
Elizabeth C FingerRobarts Institute, Western University, 100 Perth Drive, London, ON, Canada.
Derek G V MitchellBrain and Mind Institute, Western Interdisciplinary Research Building, Room 3190, Western University, London, ON, N6A 5B7, Canada. dmitch8@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Youths with high levels of callous-unemotional (CU) traits and aggression are at an increased risk for developing antisocial behaviours into adulthood. In this population, neurostructural grey matter abnormalities have been observed in the prefrontal cortex. However, the directionality of these associations is inconsistent, prompting some to suggest they may vary across development. Although similar neurodevelopmental patterns have been observed for other disorders featuring emotional and behavioural dysregulation, few studies have tested this hypothesis for CU traits, and particularly not for aggression subtypes. The current study sought to examine grey matter correlates of CU traits and aggression (including its subtypes), and then determine whether these associations varied by age. Fifty-four youths (10-19 years old) who were characterized for CU traits and aggression underwent MRI. Grey matter volume and surface area within the anterior cingulate cortex was positively associated with CU traits. The correlation between CU traits and medial orbitofrontal cortex (mOFC) volume varied significantly as a function of age, as did the correlation between reactive aggression and mOFC surface area. These associations became more positive with age. There were no significant findings for proactive/total aggression. Results are interpreted considering the potential for delayed cortical maturation in youths with high CU traits/aggression.

Indexed as

Conduct DisorderAdolescentAdultAggressionAntisocial Personality DisorderChildEmotionsHumansPrefrontal CortexYoung Adult

Identifiers

PMID38374428
PMCPMC10876571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.