Evidence map›Paper›PMID 38374394›Full record

ArticleScientific reports2024

A dual-crosslinking electroactive hydrogel based on gelatin methacrylate and dibenzaldehyde-terminated telechelic polyethylene glycol for 3D bio-printing.

Yulong Wang, Songsong Yang, Heqing Cai, Hailong Hu, Kun Hu, Zhicheng Sun, Ruping Liu, Yen Wei, Lu Han

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yulong WangThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Songsong YangThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Heqing CaiThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Hailong HuThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Kun HuThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Zhicheng SunThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Ruping LiuThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China.
Yen WeiThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China. weiyen@tsinghua.edu.cn.
Lu HanThe Engineering Research Center of 3D Printing and Bio-Fabrication, Beijing Institute of Graphic Communication, Beijing, 102600, China. hanlu@iccas.ac.cn.
Beijing Institute of Graphic Communication · CNGuangxi University · CN

Funding

National Key Research and Development Program of China No. 2022YFC2305005Scientific Research Innovation Project from Beijing Institute of Graphic Communication No. Ea202205the International Cooperation and Exchanges Program of the National Natural Science Foundation of China No 62211530446the National Natural Science Foundation of China No.22278037the National Natural Science Foundation of China No.62371051
6 · The paper itself

Abstract

Gelatin was widely used as scaffold materials in 3D bio-printing due to its excellent bioactivity and availability and especially that their arginine-glycine-aspartic acid (RGD) sequences could efficiently promote cell adhesion and proliferation. In this study, an electroactive and 3D bio-printable hydrogel was prepared through a two-step chemical cross-linking process. Specifically, residual free amino groups of methacrylated gelatin (GelMA) were cross-linked with the aldehyde groups of dibenzaldehyde-terminated telechelic polyethylene glycol (DF-PEG) via Schiff base bonds, forming a gel at 37 °C. During the subsequent 3D bio-printing process, GelMA underwent UV curing, forming a secondary cross-linked network to the mechanical strength and stability of the printed structure. The uniform dispersion of carbon nanotubes (CNTs) in the GelMA/DF-PEG composite hydrogel significantly increased its conductivity. The optimized GelMA/DF-PEG composite hydrogel, i.e., 30% GelMA and 25% DF-PEG (G30D25-CNTs), exhibited superior bio-printability. When the content of CNTs was above 4%, the conductivity of G30D25-CNTs hydrogel exceeded 10

Indexed as

BioprintingNanotubes, CarbonBiocompatible MaterialsGelatinHydrogelsMethacrylatesPolyethylene GlycolsPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsBiocompatible MaterialsGelatinHydrogelsMethacrylatesNanotubes, CarbonPolyethylene Glycols

Identifiers

PMID38374394
PMCPMC10876640
OpenAlexW4391926217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.