Evidence map›Paper›PMID 38374177›Full record

ArticleScientific reports2024

Development of a digital intervention for psychedelic preparation (DIPP).

Rosalind G McAlpine, Matthew D Sacchet, Otto Simonsson, Maisha Khan, Katarina Krajnovic, Larisa Morometescu, Sunjeev K Kamboj

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Speech markers of psychological change following a psychedelic 5-MeO-DMT retreat.Journal of psychopharmacology (Oxford, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosalind G McAlpineClinical Psychopharmacology Unit, Clinical, Educational and Health Psychology, University College London, London, UK. rosalind.mcalpine.18@ucl.ac.uk.
Matthew D SacchetMeditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Otto SimonssonDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Maisha KhanClinical Psychopharmacology Unit, Clinical, Educational and Health Psychology, University College London, London, UK.
Katarina KrajnovicClinical Psychopharmacology Unit, Clinical, Educational and Health Psychology, University College London, London, UK.
Larisa MorometescuClinical Psychopharmacology Unit, Clinical, Educational and Health Psychology, University College London, London, UK.
Sunjeev K KambojClinical Psychopharmacology Unit, Clinical, Educational and Health Psychology, University College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Psychedelic substances induce profound alterations in consciousness. Careful preparation is therefore essential to limit adverse reactions, enhance therapeutic benefits, and maintain user safety. This paper describes the development of a self-directed, digital intervention for psychedelic preparation. Drawing on elements from the UK Medical Research Council (MRC) framework for developing complex interventions, the design was informed by a four-factor model of psychedelic preparedness, using a person-centred approach. Our mixed-methods investigation consisted of two studies. The first involved interviews with 19 participants who had previously attended a 'high-dose' psilocybin retreat, systematically exploring their preparation behaviours and perspectives on the proposed intervention. The second study engaged 28 attendees of an ongoing psilocybin retreat in co-design workshops, refining the intervention protocol using insights from the initial interviews. The outcome is a co-produced 21-day digital course (Digital Intervention for Psychedelic Preparation (DIPP)), that is organised into four modules: Knowledge-Expectation, Psychophysical-Readiness, Safety-Planning, and Intention-Preparation. Fundamental components of the course include daily meditation practice, supplementary exercises tied to the weekly modules, and mood tracking. DIPP provides a comprehensive and scalable solution to enhance psychedelic preparedness, aligning with the broader shift towards digital mental health interventions.

Indexed as

HallucinogensConsciousnessHumansMental HealthPentamidinePsilocybin1,3-di(4-imidazolinophenoxyl)propaneHallucinogensPentamidinePsilocybinCo-designDigital interventionMeditationPerson-centredPsilocybinPsychedelic preparednessPsychedelicsPsychedelic therapyQualitative

Identifiers

PMID38374177
PMCPMC10876638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.