Evidence map›Paper›PMID 38374076›Full record

ArticleNature communications2024

Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.

María Ángeles Márquez-Moñino, Raquel Ortega-García, Hayley Whitfield, Andrew M Riley, Lourdes Infantes, Shane W Garrett, Megan L Shipton, Charles A Brearley, Barry V L Potter, Beatriz González

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Arg1 frommBio · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

María Ángeles Márquez-MoñinoDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain.ORCID 0000-0003-4177-9359
Raquel Ortega-GarcíaDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain.
Hayley Whitfield *School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Andrew M Riley *Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.ORCID 0000-0001-9003-3540
Lourdes InfantesDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain.ORCID 0000-0001-6932-4212
Shane W GarrettWolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Megan L ShiptonDrug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.ORCID 0000-0002-9982-0927
Charles A BrearleySchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID 0000-0001-6179-9109
Barry V L PotterDrug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. barry.potter@pharm.ox.ac.uk.ORCID 0000-0003-3255-9135
Beatriz GonzálezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain. xbeatriz@iqf.csic.es.ORCID 0000-0002-0710-0202
Consejo Superior de Investigaciones Científicas · ESUniversity of Oxford · GBUniversity of East Anglia · GBUniversity of Bath · GB

Funding

Wellcome Trust 101010
6 · The paper itself

Abstract

D-myo-inositol 1,4,5-trisphosphate (InsP

Indexed as

Inositol 1,4,5-TrisphosphatePhosphotransferases (Alcohol Group Acceptor)CalciumCatalytic DomainInositol 1,4,5-Trisphosphate ReceptorsInositol PhosphatesLigandsCalciumInositol 1,4,5-TrisphosphateInositol 1,4,5-trisphosphate 3-kinaseInositol 1,4,5-Trisphosphate ReceptorsInositol PhosphatesLigandsPhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID38374076
PMCPMC10876669
OpenAlexW4391931039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.