ArticleNature communications2024
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study.
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In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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0cells of the map it votes in
12citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Lower Virulence, Lasting Impact: Cardiovascular Consequences of Hospitalized COVID-19 in the Omicron Era.Circulation. Population health and outcomes · 2026Article
- Beyond the blood: Tissue-resident immunity shapes SARS-CoV-2 vaccine antibody responses.bioRxiv : the preprint server for biology · 2026Article
- Adherence to the Mediterranean diet, particularly olive oil intake, and metabolic health parameters are independently associated with SARS-CoV-2 vaccine-induced IgG responses.Metabolism open · 2026Article
- Real-world immune dynamics following COVID-19 vaccination and breakthrough infection: a paired-sample study in Zhejiang Province, China.Frontiers in immunology · 2026Article
- Emergence of SARS-CoV-2 Omicron lineages shifted antibody-mediated protection curves.iScience · 2025Article
- Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study.American journal of respiratory and critical care medicine · 2025Article
- Predicting antibody kinetics and duration of protection against SARS-CoV-2 following vaccination from sparse serological data.PLoS computational biology · 2025Article
- Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study.Open forum infectious diseases · 2025Article
- Obesity does not influence SARS-CoV-2 humoral vaccine immunogenicity.NPJ vaccines · 2024Article
- Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots.bioRxiv : the preprint server for biology · 2024Article
- GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 18 institutions in 1 country.
John S KimDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-8887-150X
Yifei SunDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.
Pallavi BalteDepartment of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.ORCID 0000-0002-7871-6143
Rebekah BoyleDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Russell P TracyDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Linda M StyerDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Taison D BellDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Michaela R AndersonDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Norrina B AllenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-6993-4384
Pamela J SchreinerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
David A SchwartzDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Joyce S LeeDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Vanessa XanthakisDepartment of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Margaret F DoyleDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Elizabeth A ReganDivision of Rheumatology, National Jewish Health, Denver, CO, USA.
Barry J MakeDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Alka M KanayaDivision of General Internal Medicine, University of California San Francisco, San Francisco, CA, USA.
Sally E WenzelDepartment of Medicine, Department of Immunology, and Department of Environmental Medicine and Occupational Health, University of Pittsburgh School of Medicine, School of Public Health, Pittsburgh, PA, USA.ORCID 0000-0002-4242-0164
Josef CoreshDepartment of Population Health, New York University Grossman School of Medicine, New York University Langone Health, New York, NY, USA.ORCID 0000-0002-4598-0669
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-2700-9593
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Mitchell S V ElkindDepartment of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor E OrtegaDivision of Respiratory Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Prescott WoodruffDivision of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Joel M HendersonDepartment of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA.
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.ORCID 0000-0002-5083-8640
Monica M ParkerDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Ryan T Demmer *Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. demmer.ryan@mayo.edu.
Elizabeth C Oelsner *Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. eco7@cumc.columbia.edu.ORCID 0000-0002-7481-9671
Columbia University · USUniversity of Vermont · USNational Jewish Health · USNew York State Department of Health · USBoston University · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Minnesota · USUniversity of Virginia · USAlbert Einstein College of Medicine · USMayo Clinic in Arizona · USNew York University · USNorthwestern University · USTexas Biomedical Research Institute · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Pittsburgh · US
Funding
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7MLarge Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MThe Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2MVCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
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Abstract
This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% were female, and 76% were non-Hispanic White. Nearly 52% of participants received the BNT162b2 vaccine and 48% received the mRNA-1273 vaccine. Lower anti-S1 antibody levels are associated with age of 65 years or older, male sex, higher body mass index, smoking, diabetes, COPD and receipt of BNT16b2 vaccine (vs mRNA-1273). Participants with a prior infection, particularly those with a history of hospitalized illness, have higher anti-S1 antibody levels. These results suggest that adults with certain socio-demographic and clinical characteristics may have less robust antibody responses to COVID-19 vaccination and could be prioritized for more frequent re-vaccination.
Indexed as
2019-nCoV Vaccine mRNA-1273COVID-19AdultAgedAntibodies, ViralAntibody FormationBNT162 VaccineCOVID-19 VaccinesDemographyFemaleHumansMaleSARS-CoV-2Vaccination2019-nCoV Vaccine mRNA-1273Antibodies, ViralBNT162 VaccineCOVID-19 Vaccines
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