Evidence map›Paper›PMID 38374002›Full record

ArticleBMC geriatrics2024

Susceptibility to eye diseases in relation to age and kidney failure among Taiwanese adults.

Shin-Lin Chiu, Oswald Ndi Nfor, Chiu-Liang Chen, Disline Manli Tantoh, Wen Yu Lu, Pei-Hsin Chen, Yung-Po Liaw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shin-Lin ChiuDepartment of Ophthalmology, Changhua Christian Hospital, 500, Changhua City, Taiwan.
Oswald Ndi NforDepartment of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, 40201, Taichung City, Taiwan.
Chiu-Liang ChenDepartment of Orthopedics, Changhua Christian Hospital, 500, Changhua City, Taiwan.
Disline Manli TantohDepartment of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, 40201, Taichung City, Taiwan.
Wen Yu LuDepartment of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, 40201, Taichung City, Taiwan.
Pei-Hsin ChenDepartment of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, 40201, Taichung City, Taiwan.
Yung-Po LiawDepartment of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, 40201, Taichung City, Taiwan. Liawyp@csmu.edu.tw.
Chung Shan Medical University · TWChanghua Christian Hospital · TWHungkuang University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 111-2121-M-040-002 and 111-2811-M-040-001
6 · The paper itself

Abstract

backgroundThe kidney and eyes share common pathways and are thought to be closely connected. Chronic kidney disease and major eye diseases, such as cataract and glaucoma, are strongly associated with age. However, further investigation is needed to understand the joint impact of age and kidney diseases on eye diseases. In this study, we assessed the risk of eye diseases in relation to age and kidney failure in Taiwanese adults.

methodsOur study included 127,561 cancer-free volunteers aged 30 to 70 years who participated in the Taiwan Biobank (TWB) project from 2008 to 2020. Information on the main exposures (kidney failure and age) and the outcome (eye diseases, including glaucoma, cataract, xerophthalmia, and retinal detachment) was collected through questionnaires.

resultsIn general, kidney failure and older age were independently associated with a higher risk of eye, particularly cataract and retinal detachment: prevalence odds ratio (POR); 95% confidence interval (CI) = 2.480; 1.635-3.761 for cataract and 3.885; 1.968-7.666 for retinal detachment. A significant interaction between kidney failure and age on cataract was observed (p-value = 0.0002). Age-stratified analysis revealed a higher risk of cataract among patients with kidney failure aged below 50 (POR = 6.534; 95% CI = 2.493-17.124) and between 50 and 60 years (POR = 3.957; 95%CI = 1.986-7.881). Combining kidney failure and age (reference: no kidney failure and age < 50 years), kidney failure in all age groups was associated with a higher risk of cataract. The PORs; 95% CIs were 10.725; 4.227-27.211 for patients below 50 years, 28.487; 14.270-56.866 for those aged 50-60 years, and 43.183; 24.434-72.824 for those > 60 years. Combining cataract and age (reference: no cataract and age < 50 years), patients below 50 years had the highest risk of kidney failure (POR; 95% CI = 9.510; 3.722-24.297).

conclusionsOur study suggests that age and kidney failure may jointly contribute to eye diseases, particularly cataract. The association between cataract and kidney failure could be bidirectional, especially in individuals below 50 years. This significant bidirectional relationship underscores the need for screening patients with cataract for kidney failure and vice versa, particularly in younger adults.

Indexed as

CataractGlaucomaRenal Insufficiency, ChronicRetinal DetachmentHumansRisk FactorsSurveys and QuestionnairesAgeCataractEye diseasesInteractionKidney failureTaiwanese

Identifiers

PMID38374002
PMCPMC10875750
OpenAlexW4391941190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.