SynthesisBMC musculoskeletal disorders2024
Systematic review and meta-analysis of single-stage vs two-stage revision for periprosthetic joint infection: a call for a prospective randomized trial.
Synthesis in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Antibiotic duration in native and periprosthetic joint infections : a systematic review and meta-analysis of randomized controlled trials.Bone & joint open · 2026Pooled it
- Predicting 5-Year Mortality After Prosthetic Joint Infection Using a 30-Item Accumulated Frailty Index in a 13,371-Patient Multicenter Cohort.Arthroplasty today · 2026Article
- One- vs. Two-Stage Exchange for Chronic Hip Periprosthetic Joint Infection: A Framework Based on Patient Treatment Burden and Institutional Capability.JBJS reviews · 2026Review
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
- One-Stage Revision for Low-Grade Periprosthetic Infection with Staphylococcus hominis Following Cruciate-Retaining Total Knee Arthroplasty: Case Report and Literature Review.Journal of orthopaedic case reports · 2026Article
- Chronic infections of knee megaprostheses: are "Off-Label" DAIR-Plus or partial two-stage exchange viable options?Archives of orthopaedic and trauma surgery · 2026Article
- Reevaluation of surgical strategies for chronic periprosthetic joint infection: a comparison of short-term outcomes between one-stage and two-stage revision.Frontiers in cellular and infection microbiology · 2026Article
- Surgical revision in the presence of an S. aureus infection increases virulence factor expression and activates a multi-tissue inflammatory response.NPJ biofilms and microbiomes · 2025Article
- Article
- [Revision analysis and successful solutions for my failed primary total knee arthroplasties].Orthopadie (Heidelberg, Germany) · 2025Review
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- Single-Stage Revision for Treatment of Prosthetic Joint Infection in Total Hip Arthroplasty.Indian journal of orthopaedics · 2025Review
- The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint.Infectious disease reports · 2025Article
- MIKROBE: a feasibility study for a randomised controlled trial of one-stage or two-stage surgery for prosthetic knee infection.Pilot and feasibility studies · 2025Article
- Preoperative Synovial Fluid Cultures, and Biopsy Cultures After Dry Tap Aspiration, Are Valuable in Diagnosing a Periprosthetic Joint Infection: A Retrospective Study.Microorganisms · 2025Article
- A Narrative Review of Fungal Periprosthetic Joint Infections of the Hip and Knee: Risk Factors, Microbiological Profiles, and Treatment Challenges.Journal of clinical medicine · 2025Review
- Case Report: Rheumatoid arthritis patient with hip joint infection and acetabular protrusion undergoing total hip arthroplasty: a case study and literature review.Frontiers in surgery · 2025Article
- Periprosthetic Joint Infection (PJI).The archives of bone and joint surgery · 2025Review
- Periprosthetic joint infections - a scoping review.Innovative surgical sciences · 2024Article
- Review of recent advances in the diagnosis and management of periprosthetic joint infection after total knee arthroplasty part 2: single-stage or two-stage surgical technique?Journal of orthopaedic surgery and research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriprosthetic joint infection (PJI) is a severe complication of joint arthroplasty that causes significant pain and economic loss. This study aimed to determine whether the current evidence supports single-stage revision for PJI based on reinfection and reoperation rates.
methodsWe searched the PubMed, EBSCO, Medline, and Cochrane Library databases from inception to 30 May 2023 to identify studies that compared single-stage revision and two-stage revision for PJI. Data on reinfection and reoperation rates were pooled.
resultsThis meta-analysis included a total of 40 studies with 8711 patients. Overall, there was no significant difference between single- and two-stage revision regarding the postoperative reinfection rate and reoperation rate. Subgroup analysis by surgery period and different surgical sites revealed no difference between the two groups in the reinfection and reoperation rates.
conclusionsBased on the available evidence, our study did not identify a significant difference in reinfection and reoperation rates between single- and two-stage revision for PJI. Given the limitations in inclusion/exclusion criteria and the observed heterogeneity, we acknowledge the complexity of drawing strong conclusions. Therefore, we suggest that the choice between single- and two-stage revision should be carefully considered on an individual basis, taking into account patient-specific factors and further research developments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.