ArticleInternational journal of radiation oncology, biology, physics2024
Clinical Experience With an Offline Adaptive Radiation Therapy Head and Neck Program: Dosimetric Benefits and Opportunities for Patient Selection.
Article in International journal of radiation oncology, biology, physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Predicting the benefit of adaptive radiotherapy in head and neck Cancer using cone-beam computed tomography.Physics and imaging in radiation oncology · 2026Article
- Early Salivary Gland Shrinkage Is Associated With an Increased Risk of Acute Xerostomia in Head and Neck Cancer Radiation Therapy.Advances in radiation oncology · 2026Article
- Synthetic CT-enabled weekly adaptive radiotherapy for nasopharyngeal carcinoma: Optimizing plan adaptation triggers through volumetric-dosimetric monitoring.Journal of applied clinical medical physics · 2026Article
- Beyond auto-segmentation: the case for planning and dosimetry AI in head and neck radiation oncology.BMJ oncology · 2026Review
- Deep learning-based head and neck deformable image registration using spatio-temporal analysis and self attention.Physics and imaging in radiation oncology · 2026Article
- Positioning accuracy and dosimetric evaluation of customized immobilization for FBCT guided VMAT in nasopharyngeal carcinoma.Scientific reports · 2025Article
- Nasopharyngeal cancer adaptive radiotherapy with CBCT-derived synthetic CT: deep learning-based auto-segmentation precision and dose calculation consistency on a C-Arm linac.Radiation oncology (London, England) · 2025Article
- Hounsfield Unit characterization and dose calculation on a C-arm linac with novel on-board cone-beam computed tomography feature and advanced reconstruction algorithms.Journal of applied clinical medical physics · 2025Article
- An offline adaptive planning method based on delivered accumulated dose for brachytherapy in cervical cancer.Clinical and translational radiation oncology · 2025Article
- Multi-modality imaging parameters that predict rapid tumor regression in head and neck radiotherapy.Physics and imaging in radiation oncology · 2024Article
- Preliminary experience using MR-guided adaptive radiotherapy in head and neck cancer.Frontiers in oncology · 2024Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe objective of this study was to develop a linear accelerator (LINAC)-based adaptive radiation therapy (ART) workflow for the head and neck that is informed by automated image tracking to identify major anatomic changes warranting adaptation. In this study, we report our initial clinical experience with the program and an investigation into potential trigger signals for ART. METHODS AND MATERIALS: Offline ART was systematically performed on patients receiving radiation therapy for head and neck cancer on C-arm LINACs. Adaptations were performed at a single time point during treatment with resimulation approximately 3 weeks into treatment. Throughout treatment, all patients were tracked using an automated image tracking system called the Automated Watchdog for Adaptive Radiotherapy Environment (AWARE). AWARE measures volumetric changes in gross tumor volumes (GTVs) and selected normal tissues via cone beam computed tomography scans and deformable registration. The benefit of ART was determined by comparing adaptive plan dosimetry and normal tissue complication probabilities against the initial plans recalculated on resimulation computed tomography scans. Dosimetric differences were then correlated with AWARE-measured volume changes to identify patient-specific triggers for ART. Candidate trigger variables were evaluated using receiver operator characteristic analysis.
resultsIn total, 46 patients received ART in this study. Among these patients, we observed a significant decrease in dose to the submandibular glands (mean ± standard deviation: -219.2 ± 291.2 cGy, P < 10
conclusionsSystematic offline head and neck ART was successfully deployed on conventional LINACs and reduced doses to critical salivary structures and the oral cavity. Automated cone beam computed tomography tracking provided information regarding anatomic changes that may aid patient-specific triggering for ART.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.