Evidence map›Paper›PMID 38373627›Full record

ArticleChemico-biological interactions2024

High incidence of sebaceous gland inflammation in aldose reductase-deficient mice.

Anjali Mandava, Binhan Pham, Michelle Pedler, Biehuoy Shieh, Hari Gopalakrishnan, J Mark Petrash

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anjali MandavaDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Binhan PhamDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Michelle PedlerDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Biehuoy ShiehDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Hari GopalakrishnanDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
J Mark PetrashDepartment of Ophthalmology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: Mark.Petrash@CUAnschutz.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Molecular Signaling in CataractsR01EY028147 · NEI · UNIVERSITY OF COLORADO DENVER · PI PETRASH, JONATHAN MARK · 2017 to 2021
$2.1M
NEI NIH HHS R01 EY028147
6 · The paper itself

Abstract

Aldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains produced using Crispr-Cas9 to inactivate the AKR1B3 gene in C57BL6 mice. Phenotyping AR-knock out (ARKO) strains confirmed previous reports of reduced accumulation of tissue sorbitol levels. Lens epithelial cells in ARKO mice showed markedly reduced epithelial-to-mesenchymal transition following lens extraction in a surgical model of cataract and posterior capsule opacification. A previously unreported phenotype of preputial sebaceous gland swelling was observed frequently in male ARKO mice homozygous for the mutant AKR1B3 allele. This condition, which was shown to be accompanied by infiltration of proinflammatory CD3

Indexed as

Capsule OpacificationCataractLens, CrystallineAldehyde ReductaseAldo-Keto ReductasesAnimalsIncidenceInflammationMaleMiceMice, Inbred C57BLMice, KnockoutSebaceous GlandsAkr1b3 protein, mouseAldehyde ReductaseAldo-Keto ReductasesAldose reductaseCRISPR-Cas9Epithelial-to-mesenchymal transitionPolyol pathwaySebaceous gland

Identifiers

PMID38373627
PMCPMC10960685
OpenAlexW4391899652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.