Article in Genes, brain, and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 2 institutions in 1 country.
S L PlasilDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
S P FarrisDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Y BlednovThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
R D MayfieldThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
R A MangieriThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
U J NwokejiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
H C AzizThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
P S LambethThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
R A HarrisThe Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0001-8870-5950
G E HomanicsDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-3641-8153
The University of Texas at Austin · USUniversity of Pittsburgh · US
Funding
INIA: ANIMAL COREU01AA013520 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI YURI A BLEDNOV, ROBERT O. MESSING · 2001 to 2026
$9.5M
Role of noncoding RNA in alcohol actionU01AA020889 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris, Gregg E. Homanics · 2011 to 2026
$7.1M
Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
Next Generation Sequencing of Human Alcoholic BrainU01AA020926 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Roy DAYNE MAYFIELD · 2011 to 2026
$6.7M
Target Validation byAccumbal Plasticity ScreeningU01AA016651 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Regina A. Mangieri · 2006 to 2026
$3.8M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4M
Target Validation Electrophysiology CoreU24AA016651 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MANGIERI, REGINA A. · 2015 to 2021
$1.7M
Long Non-Coding RNA Regulation of Alcohol Drinking BehaviorR00AA024836 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FARRIS, SEAN P · 2020 to 2022
$667k
LONG NON-CODING RNA REGULATION OF ALCOHOL DRINKING BEHAVIORK99AA024836 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FARRIS, SEAN P · 2017 to 2018
$306k
lncRNA Gas5 dysregulation alters ethanol drinking behavior and ethanol-related phenotypesF31AA030176 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PLASIL, SONJA LOREAN · 2022 to 2022
Chronic alcohol exposure results in widespread dysregulation of gene expression that contributes to the pathogenesis of Alcohol Use Disorder (AUD). Long noncoding RNAs are key regulators of the transcriptome that we hypothesize coordinate alcohol-induced transcriptome dysregulation and contribute to AUD. Based on RNA-Sequencing data of human prefrontal cortex, basolateral amygdala and nucleus accumbens of AUD versus non-AUD brain, the human LINC01265 and its predicted murine homolog Gm41261 (i.e., TX2) were selected for functional interrogation. We tested the hypothesis that TX2 contributes to ethanol drinking and behavioral responses to ethanol. CRISPR/Cas9 mutagenesis was used to create a TX2 mutant mouse line in which 306 base-pairs were deleted from the locus. RNA analysis revealed that an abnormal TX2 transcript was produced at an unchanged level in mutant animals. Behaviorally, mutant mice had reduced ethanol, gaboxadol and zolpidem-induced loss of the righting response and reduced tolerance to ethanol in both sexes. In addition, a male-specific reduction in two-bottle choice every-other-day ethanol drinking was observed. Male TX2 mutants exhibited evidence of enhanced GABA release and altered GABA
Indexed as
AlcoholismRNA, Long NoncodingAlcohol DrinkingAnimalsEthanolFemaleHumansMaleMiceMice, Inbred C57BLMutationReceptors, GABA-AEthanolReceptors, GABA-ARNA, Long Noncodingalcohol use disorderbehavioral analysisCRISPR/Cas9electrophysiologygene-targetedgeneticslong noncoding RNAmolecular analysismousemutagenesis
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice. · full record | OpenQuestion