Evidence map›Paper›PMID 38373075›Full record

ArticleCancer2024

Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.

Ellen van der Plas, Himani Darji, Deo K Srivastava, Melissa Schapiro, Donna Jeffe, Stephanie Perkins, Rebecca Howell, Wendy Leisenring, Gregory T Armstrong, Kevin Oeffinger and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Ellen van der PlasDepartment of Hematology/Oncology, Arkansas Children's Hospital, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0002-7490-6636
Himani DarjiQuantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, California, USA.
Deo K SrivastavaBiostatistics Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Melissa SchapiroDepartment of Pediatrics, SSM Health Cardinal Glennon Children's Hospital-St. Louis University, St. Louis, Missouri, USA.
Donna JeffeJohn T. Milliken Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Stephanie PerkinsDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Rebecca HowellDepartment of Radiation Physics, The MD Anderson Cancer Center, Houston, Texas, USA.
Wendy LeisenringClinical Research Division, Fred Hutch Cancer Center, Seattle, Washington, USA.
Gregory T ArmstrongEpidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kevin OeffingerDepartment of Medicine, Duke University, Durham, North Carolina, USA.
Kevin KrullPsychology and Biobehavioral Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-0476-7001
Kim EdelsteinDepartment of Supportive Care, Princess Margaret Cancer Center, Toronto, Ontario, Canada.
Robert J HayashiWashington University School of Medicine in St. Louis, Department of Pediatrics, St. Louis Childrens Hospital, Siteman Cancer Center, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-1140-1139
St. Jude Children's Research Hospital · USWashington University in St. Louis · USArkansas Children's Hospital · USCardinal Glennon Children’s Medical Center · USDuke University · USFred Hutch Cancer Center · USPrincess Margaret Cancer Centre · CASt. Louis Children's Hospital · USThe University of Texas MD Anderson Cancer Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
CHILDHOOD CANCER SURVIVOR STUDYU01CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROBISON, LESLIE L · 1993 to 1999
–
American Lebanese Syrian Associated CharitiesNCI NIH HHS CA 21765NCI NIH HHS CA55727NCI NIH HHS P30 CA021765NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

backgroundPrevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well-established.

methodsParticipants in this cross-sectional, case-control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health-related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, and chronic conditions associated with impairment.

resultsRelative to siblings, more survivors reported neurocognitive impairment (task efficiency: 21.1% vs. 13.7%, emotional regulation: 16.7% vs. 11.0%, memory: 19.3% vs. 15.1%), elevated emotional distress (somatic distress: 12.9% vs. 4.7%, anxiety: 11.7% vs. 5.9%, depression: 22.8% vs. 16.9%) and poorer HRQOL (physical functioning: 11.1% vs. 2.8%, role functioning due to physical problems: 16.8% vs. 8.2%, pain: 17.5% vs. 10.0%, vitality: 22.3% vs. 13.8%, social functioning: 14.4% vs. 6.8%, emotional functioning: 17.1% vs. 10.6%). Cranial radiation increased risk for impaired task efficiency (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.14-4.63), whereas chest and pelvic radiation predicted increased risk of physical functioning (OR, 2.68; 95% CI, 1.16-6.21 and OR, 3.44; 95% CI, 1.70-6.95, respectively). Smoking was associated with impaired task efficiency (OR, 2.06; 95% CI, 1.14-3.70), memory (OR, 2.23; 95% CI, 1.26-3.95), anxiety (OR, 2.71; 95% CI, 1.36-5.41) and depression (OR, 1.77; 95% CI, 1.01-3.11). Neurologic conditions increased risk of anxiety (OR, 2.30; 95% CI, 1.04-5.10), and hearing conditions increased risk of depression (OR, 1.79; 95% CI, 1.05-3.03). Neurologic and hearing conditions, respectively, were associated with impaired memory (OR, 2.44; 95% CI, 1.20-4.95 and OR, 1.87; 95% CI, 1.05-3.35) and poor health perception (OR, 2.62; 95% CI, 1.62-1.28 and OR, 2.33; 95% CI, 1.34-4.06).

conclusionsRMS survivors are at significant risk for poor psychological outcomes. Advancing therapies for local control, smoking cessation, and managing chronic medical conditions may mitigate poor outcomes following RMS.

Indexed as

Cancer SurvivorsPsychological DistressQuality of LifeRhabdomyosarcomaAdolescentAdultAnxietyCase-Control StudiesChildCross-Sectional StudiesFemaleHumansMaleRisk FactorsYoung Adultcognitionpsychological distressquality of liferhabdomyosarcomasurveys and questionnairessurvivorship

Identifiers

PMID38373075
PMCPMC11139574
OpenAlexW4391925003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.