Evidence map›Paper›PMID 38372937›Full record

ArticleProbiotics and antimicrobial proteins2025

In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide.

Zhongjie Li, Yingbin Shui, Huayi Wang, Shasha Li, Bo Deng, Wenlu Zhang, Shegan Gao, Lingyu Zhao

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhongjie LiInstitute of Genetics and Developmental Biology, Translational Medicine Institute, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710049, China. sui_feng5217@126.com.
Yingbin ShuiMicrobial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
Huayi WangMicrobial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
Shasha LiMicrobial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
Bo DengMicrobial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
Wenlu ZhangMicrobial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
Shegan GaoHenan Provincial Key Laboratory of Microbiota and Esophageal Cancer Prevention and Control, Henan University of Science and Technology, Luoyang, 471000, China. gsg112258@163.com.
Lingyu ZhaoInstitute of Genetics and Developmental Biology, Translational Medicine Institute, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710049, China. zhaolingyu@xjtu.edu.cn.
Henan University of Science and Technology · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections.

Indexed as

Antifungal AgentsAntimicrobial PeptidesCandida albicansCandidiasisScorpionsAnimalsBiofilmsFemaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsReactive Oxygen SpeciesAntifungal AgentsAntimicrobial PeptidesReactive Oxygen SpeciesAntimicrobial peptideCandida albicansNecrosisSkin infection

Identifiers

PMID38372937
OpenAlexW4391988674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.