Evidence map›Paper›PMID 38372786›Full record

ArticleWorld journal of urology2024

The association between patient and disease characteristics, and the risk of disease progression in patients with prostate cancer on active surveillance.

Matthijs Duijn, Theo M de Reijke, Kurdo Barwari, Marias J Hagens, Sybren P Rynja, Jos Immerzeel, Jelle O Barentsz, Auke Jager

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in World journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Matthijs DuijnDepartment of Urology, OLVG, PO Box 95500, 1090 HM, Amsterdam, The Netherlands. matthijsduijn@hotmail.nl.ORCID http://orcid.org/0000-0001-8752-6176
Theo M de ReijkeAndros Clinics, Arnhem, The Netherlands.
Kurdo BarwariAndros Clinics, Arnhem, The Netherlands.
Marias J HagensDepartment of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Sybren P RynjaDepartment of Urology, Spaarne Gasthuis, Hoofddorp, The Netherlands.
Jos ImmerzeelAndros Clinics, Arnhem, The Netherlands.
Jelle O BarentszAndros Clinics, Arnhem, The Netherlands.
Auke JagerDepartment of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Andros Mannenkliniek · NLOncode Institute · NLAmsterdam University Medical Centers · NLNetherlands Aerospace Centre · NLSpaarne Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study was to identify and assess patient and disease characteristics associated with an increased risk of disease progression in men with prostate cancer on active surveillance.

methodsWe studied patients with low-risk (ISUP GG1) or favorable intermediate-risk (ISUP GG2) PCa. All patients had at least one repeat biopsy. Disease progression was the primary outcome of this study, based on pathological upgrading. Univariate and multivariate Cox proportional hazard analyses were used to evaluate the association between covariates and disease progression.

resultsIn total, 240 men were included, of whom 198 (82.5%) were diagnosed with low-risk PCa and 42 (17.5%) with favorable intermediate-risk PCa. Disease progression was observed in 42.9% (103/240) of men. Index lesion > 10 mm (HR = 2.85; 95% CI 1.74-4.68; p < 0.001), MRI (m)T-stage 2b/2c (HR = 2.52; 95% CI 1.16-5.50; p = 0.02), highest PI-RADS score of 5 (HR 3.05; 95% CI 1.48-6.28; p = 0.002) and a higher PSA level (HR 1.06; 95% CI 1.01-1.11; p = 0.014) at baseline were associated with disease progression on univariate analysis. Multivariate analysis showed no significant baseline predictors of disease progression.

conclusionIn AS patients with low-risk or favorable intermediate-risk PCa, diameter of index lesion, MRI (m)T-stage, height of the PI-RADS score and the PSA level at baseline are significant predictors of disease progression to first repeat biopsy.

Indexed as

Prostatic NeoplasmsDisease ProgressionHumansMagnetic Resonance ImagingMaleProstate-Specific AntigenWatchful WaitingProstate-Specific AntigenActive surveillanceDisease progressionIntermediate-risk prostate cancerLow-risk prostate cancerProstate cancerSwitching to active treatment

Identifiers

PMID38372786
OpenAlexW4391945711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.