Evidence map›Paper›PMID 38372643›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2024

Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study.

Arthur Bookstein, Justine Po, Chiuchen Tseng, Timothy V Larson, Juan Yang, Sung-Shim L Park, Jun Wu, Salma Shariff-Marco, Pushkar P Inamdar, Ugonna Ihenacho and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
    Pooled it
  2. Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Arthur Bookstein *Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-8218-0401
Justine Po *Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-5399-2208
Chiuchen TsengDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0009-0000-4612-9481
Timothy V LarsonDepartments of Civil & Environmental Engineering and Environmental &, Occupational Health Sciences, University of Washington, Seattle, Washington.ORCID 0000-0003-2208-982X
Juan YangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-2291-7907
Sung-Shim L ParkPopulation Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0003-2818-4705
Jun WuDepartment of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, Irvine, California.ORCID 0000-0002-2693-7112
Salma Shariff-MarcoDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-2541-3333
Pushkar P InamdarDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-2648-2477
Ugonna IhenachoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-9469-8184
Veronica W SetiawanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-9239-5692
Mindy C DeRouenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-7198-7629
Loïc Le MarchandPopulation Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0001-5013-980X
Daniel O StramDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-7099-9022
Jonathan SametDepartments of Epidemiology and of Environmental & Occupational Health, Colorado School of Public Health, Aurora, Colorado.ORCID 0000-0001-5676-9175
Beate RitzDepartment of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-6976-7339
Scott FruinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-2953-0457
Anna H Wu *Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0003-0546-902X
Iona Cheng *Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-4132-2893
University of Southern California · USUniversity of California, San Francisco · USCancer Center of Hawaii · USColorado School of Public Health · USLos Angeles County Department of Public Health · USSamueli Institute · USUniversity of Washington · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
A cohort study of air pollution, lung cancer, and COPD in Los Angeles CountyR01ES026171 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, IONA C, WU, ANNA H. · 2016 to 2019
$2.1M
NCI NIH HHS T32 CA229110NCI NIH HHS U01 CA164973NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES026171
6 · The paper itself

Abstract

backgroundUltrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County.

methodsWithin the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence. Multivariable Cox proportional hazards regression models were used to estimate the effect of UFP exposure on lung cancer incidence. Subgroup analyses by demographics, histology and smoking status were conducted.

resultsAirport-related UFP exposure was not associated with lung cancer risk [per one IGR HR, 1.01; 95% confidence interval (CI), 0.97-1.05] overall and across race/ethnicity. A suggestive positive association was observed between a one IQR increase in UFP exposure and lung squamous cell carcinoma (SCC) risk (HR, 1.08; 95% CI, 1.00-1.17) with a Phet for histology = 0.05. Positive associations were observed in 5-year lag analysis for SCC (HR, 1.12; 95% CI, CI, 1.02-1.22) and large cell carcinoma risk (HR, 1.23; 95% CI, 1.01-1.49) with a Phet for histology = 0.01.

conclusionsThis large prospective cohort analysis suggests a potential association between airport-related UFP exposure and specific lung histologies. The findings align with research indicating that UFPs found in aviation exhaust may induce inflammatory and oxidative injury leading to SCC. IMPACT: These results highlight the potential role of airport-related UFP exposure in the development of lung SCC.

Indexed as

AirportsLung NeoplasmsParticulate MatterAgedAir PollutantsCohort StudiesEnvironmental ExposureEthnicityFemaleHumansIncidenceLos AngelesMaleMiddle AgedProspective StudiesRisk FactorsAir PollutantsParticulate Matter

Identifiers

PMID38372643
PMCPMC11062824
OpenAlexW4391931160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.