Evidence map›Paper›PMID 38372528›Full record

ReviewClinical science (London, England : 1979)2024

COVID-19 and abnormal uterine bleeding: potential associations and mechanisms.

Jacqueline A Maybin, Marianne Watters, Bethan Rowley, Catherine A Walker, Gemma C Sharp, Alexandra Alvergne

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Jacqueline A MaybinCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0003-1560-2840
Marianne WattersCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, U.K.
Bethan RowleyCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, U.K.
Catherine A WalkerCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, U.K.
Gemma C SharpSchool of Psychology, University of Exeter, U.K.
Alexandra AlvergneISEM, Univ Montpellier, CNRS, IRD, Montpellier, France.
MRC Centre for Regenerative Medicine · GBCentre National de la Recherche Scientifique · FRUniversity of Exeter · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The impact of COVID-19 on menstruation has received a high level of public and media interest. Despite this, uncertainty exists about the advice that women and people who menstruate should receive in relation to the expected impact of SARS-CoV-2 infection, long COVID or COVID-19 vaccination on menstruation. Furthermore, the mechanisms leading to these reported menstrual changes are poorly understood. This review evaluates the published literature on COVID-19 and its impact on menstrual bleeding, discussing the strengths and limitations of these studies. We present evidence consistent with SARS-CoV-2 infection and long COVID having an association with changes in menstrual bleeding parameters and that the impact of COVID vaccination on menstruation appears less significant. An overview of menstrual physiology and known causes of abnormal uterine bleeding (AUB) is provided before discussing potential mechanisms which may underpin the menstrual disturbance reported with COVID-19, highlighting areas for future scientific study. Finally, consideration is given to the effect that menstruation may have on COVID-19, including the impact of the ovarian sex hormones on acute COVID-19 severity and susceptibility and reported variation in long COVID symptoms across the menstrual cycle. Understanding the current evidence and addressing gaps in our knowledge in this area are essential to inform public health policy, direct the treatment of menstrual disturbance and facilitate development of new therapies, which may reduce the severity of COVID-19 and improve quality of life for those experiencing long COVID.

Indexed as

COVID-19EndometriumCOVID-19 VaccinesFemaleHumansMenstruationMenstruation DisturbancesPost-Acute COVID-19 SyndromeQuality of LifeSARS-CoV-2Uterine HemorrhageCOVID-19 VaccinesCOVIDEndometrialEndometriumMensesMenstruationUterus

Identifiers

PMID38372528
PMCPMC10876417
OpenAlexW4391940970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.