ReviewCNS neuroscience & therapeutics2024
Autonomic dysfunction and treatment strategies in intracerebral hemorrhage.
Review in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of dynamic blood glucose trajectories on mortality in critically ill non-traumatic intracranial hemorrhage patients: a retrospective cohort study.BMC neurology · 2026Article
- Admission Serum Albumin as a Predictor of Cardiovascular Complications in Non-Traumatic Intracerebral Hemorrhage.Journal of clinical medicine · 2026Article
- Early Cardiac Workload and Long-Term Prognosis After Intracerebral Hemorrhage: Insights from a Large Multicenter Cohort.Reviews in cardiovascular medicine · 2026Article
- Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms.Frontiers in immunology · 2026Review
- From sympathetic storm to systemic inflammation: spatiotemporal dynamics of the brain-lung axis in neurogenic pulmonary edema.Frontiers in neuroscience · 2026Review
- Brain heart crosstalk after ischemic stroke toward a unified framework for pathophysiology and precision medicine.Frontiers in molecular neuroscience · 2026Review
- Sevoflurane is associated with reduced EGFR-VEGF-AKT signaling in glioma tissues relative to propofol: a bioinformatics and clinical pilot study.Frontiers in oncology · 2026Article
- Lower admission reverse shock index multiplied by Glasgow coma scale score is associated with early hematoma expansion in spontaneous intracerebral hemorrhage.Frontiers in neurology · 2026Article
- Decreased 24-hour Parasympathetic Activity following Intracerebral Hemorrhage: A Key Factor Correlated with Adverse Perihematomal Edema and Poor Functional Outcomes.CNS neuroscience & therapeutics · 2026Article
- Predictors, trends and outcomes associated with urinary tract infections in intracerebral hemorrhage: insights from a National Inpatient Sample Study (2010-2022).European journal of medical research · 2025Article
- Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Emergency Department Vital Sign Variability Is Associated with Hematoma Progression in Spontaneous Intracerebral Hemorrhage.Journal of clinical medicine · 2025Article
- Central Thalamic Deep Brain Stimulation Modulates Autonomic Nervous System Responsiveness in Disorders of Consciousness.CNS neuroscience & therapeutics · 2025Article
- A novel prediction method for intracerebral hemorrhage-associated pneumonia: A single center analysis.PloS one · 2025Article
- Sympathetic overactivation and catecholamine toxicity: mechanisms and therapeutic strategies for neurogenic heart injury following acute ischemic stroke.Frontiers in cardiovascular medicine · 2025Review
- Posterior communicating artery vasospasm impairs cerebral pulsatility in an experimental subarachnoid hemorrhage model.Frontiers in neurology · 2025Article
- Heart Rate Variability and Functional Outcomes of Patients with Spontaneous Intracerebral Hemorrhage.Biomedicines · 2024Article
- Blood Pressure Variability in Acute Stroke: A Narrative Review.Journal of clinical medicine · 2024Review
- Autonomic dysfunction and treatment strategies in intracerebral hemorrhage.CNS neuroscience & therapeutics · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsAutonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical practice and research on autonomic dysfunction in ICH patients. DISCUSSION: We summarize the autonomic dysfunction in ICH from the aspects of potential mechanisms, clinical significance, assessment, and treatment strategies. The CAN structures mainly include insular cortex, anterior cingulate cortex, amygdala, hypothalamus, nucleus of the solitary tract, ventrolateral medulla, dorsal motor nucleus of the vagus, nucleus ambiguus, parabrachial nucleus, and periaqueductal gray. Autonomic dysfunction after ICH is closely associated with neurological functional outcomes, cardiac complications, blood pressure fluctuation, immunosuppression and infection, thermoregulatory dysfunction, hyperglycemia, digestive dysfunction, and urogenital disturbances. Heart rate variability, baroreflex sensitivity, skin sympathetic nerve activity, sympathetic skin response, and plasma catecholamine concentration can be used to assess the autonomic functional activities after ICH. Risk stratification of patients according to autonomic functional activities, and development of intervention approaches based on the restoration of sympathetic-parasympathetic balance, would potentially improve clinical outcomes in ICH patients.
conclusionThe review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.