Evidence map›Paper›PMID 38372383›Full record

ArticleJournal of cell science2024

C. elegans spermatocyte divisions show a weak spindle checkpoint response.

Shang-Yang Chen, Pu-Wei Cheng, Hsiao-Fang Peng, Jui-Ching Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shang-Yang ChenDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0002-1925-0523
Pu-Wei ChengDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0002-0508-4800
Hsiao-Fang PengDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0002-1938-2913
Jui-Ching WuDepartment of Clinical Laboratory Science and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0002-3880-9652
National Taiwan University · TW

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Ministry of Science and Technology MOST-106-2311-B-002-035Ministry of Science and Technology, Taiwan MOST-106-2311-B-002-035NIH HHS P40 OD010440
6 · The paper itself

Abstract

Male meiotic division exhibits two consecutive chromosome separation events without apparent pausing. Several studies have shown that spermatocyte divisions are not stringently regulated as in mitotic cells. In this study, we investigated the role of the canonical spindle assembly (SAC) pathway in Caenorhabditis elegans spermatogenesis. We found the intensity of chromosome-associated outer kinetochore protein BUB-1 and SAC effector MDF-1 oscillates between the two divisions. However, the SAC target securin is degraded during the first division and remains undetectable for the second division. Inhibition of proteasome-dependent protein degradation did not affect the progression of the second division but stopped the first division at metaphase. Perturbation of spindle integrity did not affect the duration of meiosis II, and only slightly lengthened meiosis I. Our results demonstrate that male meiosis II is independent of SAC regulation, and male meiosis I exhibits only weak checkpoint response.

Indexed as

Caenorhabditis elegansSpindle ApparatusAnimalsCell Cycle ProteinsChromosome SegregationKinetochoresMaleMeiosisOocytesSpermatocytesSpermatogenesisCell Cycle ProteinsChromosome segregationMale meiotic divisionsProteasomeSecurinSpindle assembly checkpoint

Identifiers

PMID38372383
PMCPMC11651637
OpenAlexW4391942907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.