Evidence map›Paper›PMID 38372346›Full record

ArticleMolecular carcinogenesis2024

Tissue-of-origin for cancers determines HIF-1 activation induced phenotypic heterogeneity.

Shaofei Liu, Yamin Liu, Xihua Qiu, Yasir Suhail, Kshitiz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular carcinogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shaofei LiuDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
Yamin LiuDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
Xihua QiuDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
Yasir SuhailDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
KshitizDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, Connecticut, USA.ORCID 0000-0003-4241-9427
UConn Health · US

Funding

Investigating the Role of Emergent Oscillations of Hypoxia Inducible Factor-1 alpha Activity in Cancer Growth and ProgressionR37CA248161 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KSHITIZ, . · 2020 to 2025
$2.5M
NCI NIH HHS R37 CA248161
6 · The paper itself

Abstract

Hypoxia-inducible factor-1 (HIF-1) is the master regulator of cellular response to hypoxia, and is activated in many cancers contributing to many steps in the metastatic cascade by acting as a key transcription co-regulator for a large number of downstream genes. Presence of hypoxia within a tumor is spatially nonuniform, and can also by dynamic. Further, although HIF-1 is primarily stabilized and activated by lack of molecular O

Indexed as

Colorectal NeoplasmsHypoxia-Inducible Factor 1Pancreatic NeoplasmsCell HypoxiaCell Line, TumorGene Expression Regulation, NeoplasticHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitTumor MicroenvironmentHIF1A protein, humanHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha Subunitcancer heterogeneityHIF‐1HIF‐1 heterogeneityHIF gene expressionhypoxia

Identifiers

PMID38372346
PMCPMC11013563
OpenAlexW4391926581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.