ArticleMolecular and cellular biology1985
Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype.
Article in Molecular and cellular biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 47 citations in OpenAlex.
- Roles of beta-tubulin residues Ala428 and Thr429 in microtubule formation in vivo.The Journal of biological chemistry · 2009Article
- Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae.Molecular and cellular biology · 1996Article
- A determination of the frequency of gene conversion in unmanipulated mouse sperm.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Unusual mutation clusters provide insight into class I gene conversion mechanisms.Molecular and cellular biology · 1993Article
- The beta-tubulin gene family of pea: primary structures, genomic organization and intron-dependent evolution of genes.Plant molecular biology · 1992Article
- The alpha-tubulin gene family expressed during cell differentiation in Naegleria gruberi.The Journal of cell biology · 1988Article
- A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.The EMBO journal · 1988Article
- A gene encoding the major beta tubulin of the mitotic spindle in Physarum polycephalum plasmodia.Molecular and cellular biology · 1988Article
- Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides.Molecular and cellular biology · 1988Article
- In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function.The Journal of cell biology · 1987Article
- Developmental regulation and identification of an isotype encoded by altB, an alpha-tubulin locus in Physarum polycephalum.Molecular and cellular biology · 1987Article
- Three Drosophila beta-tubulin sequences: a developmentally regulated isoform (beta 3), the testis-specific isoform (beta 2), and an assembly-defective mutation of the testis-specific isoform (B2t8) reveal both an ancient divergence in metazoan isotypes and structural constraints for beta-tubulin function.Molecular and cellular biology · 1987Article
- The multitubulin hypothesis revisited: what have we learned?The Journal of cell biology · 1987Review
- The relatively large beta-tubulin gene family of Arabidopsis contains a member with an unusual transcribed 5' noncoding sequence.Plant molecular biology · 1987Article
- Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression.Molecular and cellular biology · 1986Article
- Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We have determined the complete nucleotide sequences of two chicken beta-tubulin genes, beta 1 and beta 2. These genes display an unusual pattern of segmental homology which indicates that they originally arose by gene duplication and have subsequently coevolved by a process that included localized gene conversion or intergenic recombination. Since the beta-tubulin polypeptides encoded by the two genes are virtually identical (99.5%), particularly in the major beta-tubulin isotype defining regions, they almost certainly constitute a single isotypic class of beta tubulin. However, the regulatory properties of the two genes are highly divergent as indicated by analysis of their patterns of expression in different chicken cell types. beta 1 is the major transcript detected in skeletal muscle myoblasts, whereas beta 2 is the major beta-tubulin transcript in cultured sympathetic neurons. The existence of these two genes appears to derive from a regulatory requirement whereby the expression of a single tubulin isotype is mediated through different regulatory programs in development and differentiation. These results thus provide direct experimental support for the hypothesis that gene conversion and intergenic recombination play an important role in evolution by uncoupling the evolution of structural genes from the regulatory sequences which control them.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.