ArticleACS omega2024
Simple and Cost-Effective Quantum Dot Chemodosimeter for Visual Detection of Biothiols in Human Blood Serum.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0 citing papers in PubMed, 5 citations in OpenAlex.
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An emission "turn-off" chemodosimeter for the naked-eye detection of biothiols using silica-overcoated cadmium selenide quantum dots is developed. Hole scavenging by the thiol group of cysteine, homocysteine, or glutathione on interaction with quantum dots resulted in an instant and permanent emission quenching under physiologically relevant conditions. Also, the emission suppression is so specific that thiols and substituted thiols (methionine and cystine) can easily be distinguished. A pilot experiment for the visual detection of serum thiols in human blood was also conducted. Densitometry analysis proved the potential of this system as a new methodology in clinical chemistry and research laboratories for routine blood and urine analyses using a simple procedure. This method enables one to visually distinguish biothiols and oxidized biothiols, whose ratio plays a crucial role in maintaining "redox thiol status" in the blood.
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Registered trials
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