Evidence map›Paper›PMID 38371661›Full record

ArticleJAAD international2024

Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study.

Nathan T Harvey, Debra J Palmer, Paige Tucker, Aron Chakera, Rachael Foster, Wai Lim, Richard W Trevithick, Benjamin A Wood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAAD international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Nathan T HarveyDepartment of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
Debra J PalmerSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Paige TuckerDepartment of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
Aron ChakeraRenal Medicine and Transplantation, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Rachael FosterDermatology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Wai LimRenal Medicine and Transplantation, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Richard W TrevithickDepartment of Health, Western Australian Cancer Registry, Perth, WA, Australia.
Benjamin A WoodDepartment of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
Sir Charles Gairdner Hospital · AUThe University of Western Australia · AUGovernment of Western Australia Department of Health · AUQueen Elizabeth II Medical Centre · AUThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases. Objectives: To determine the histological parameters which have independent prognostic value for cutaneous squamous cell carcinoma arising in renal transplant recipients. Methods: Case-control study incorporating a retrospective blinded histological review of 70 archived specimens of cutaneous squamous cell carcinoma diagnosed in renal transplant recipients, comprising 10 cases where the tumor had progressed and 60 controls. Results: Progression was significantly associated with head and neck location, size, depth, poor histological grade, perineural invasion (including small caliber perineural invasion), lymphovascular invasion, and a desmoplastic growth pattern. Limitations: The retrospective nature and the low number of cases compared to controls. Conclusion: In immunosuppressed patients both small caliber perineural invasion and a desmoplastic growth pattern may also have prognostic significance in addition to other histological parameters already recognized in formal staging schemes.

Indexed as

carcinomalogistic modelsretrospective studiesskin neoplasmssquamous celltransplant recipients

Identifiers

PMID38371661
PMCPMC10869928
OpenAlexW4390365482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.