Evidence map›Paper›PMID 38371489›Full record

ArticleNeurobiology of stress2024

Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice.

Joyce Liu, Daniel J Lustberg, Abigail Galvez, L Cameron Liles, Katharine E McCann, David Weinshenker

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joyce LiuDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Daniel J LustbergDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Abigail GalvezDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
L Cameron LilesDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Katharine E McCannDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
David WeinshenkerDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · US

Funding

TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Mechanisms underlying selective vulnerability of locus coeruleus neurons in Alzheimer's diseaseRF1AG061175 · NIA · EMORY UNIVERSITY · PI KANG, SEONG SU, WEINSHENKER, DAVID · 2019 to 2019
$2.8M
Contribution of locus coeruleus-derived galanin to opioid reward and reinforcementR01DA049257 · NIDA · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2020 to 2024
$2.3M
Contribution of neuromelanin to selective vulnerability of locus coeruleus neurons in Alzheimer's diseaseRF1AG079199 · NIA · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2022 to 2024
$1.6M
NIA NIH HHS RF1 AG061175NIA NIH HHS RF1 AG079199NIDA NIH HHS R01 DA049257NINDS NIH HHS T32 NS007480
6 · The paper itself

Abstract

In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE) and dopamine (DA) modulate anxiety and predator odor responses, and we have shown previously that dopamine β-hydroxylase knockout (

Indexed as

DopamineDopamine β-hydroxylaseNorepinephrinePredatorToxoplasma gondii

Identifiers

PMID38371489
PMCPMC10873756
OpenAlexW4391469307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.