ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- AI and Wearables for Early Detection of Cognitive Impairment and Dementia: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Telomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer's risk.Alzheimer's research & therapy · 2025Trial
- Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.Neurology · 2026Article
- Night-to-night rapid eye movement sleep variability: A relevant marker of early amyloid-β deposition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Dose-Response Relationship Between Sleep Regularity Index and Stage-Specific Alzheimer's Disease: Cross-Sectional Evidence from Japanese Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Longitudinal association between sleep and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review.The journal of prevention of Alzheimer's disease · 2025Review
- Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Circadian rhythm disturbances in Alzheimer's disease: insights from plaque-free and plaque-burdened stages in APPAlzheimer's research & therapy · 2025Article
- Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults.BMC public health · 2025Article
- Impact of Mild Traumatic Brain Injury on Sleep Patterns in Younger Individuals: A Systematic Review.Neurotrauma reports · 2025Review
- The role of actigraphy in detecting and characterizing the early phases of Alzheimer's disease.Sleep · 2024Article
- Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Counting Zs: Determining the Monitoring Days Needed to Obtain Reliable Sleep Metrics in Older Adults with Mild Cognitive Impairment.Behavioral sleep medicineArticle
- Day-to-day sleep efficiency and driving behaviors in older adults with and without cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Interdaily variability of rest-activity patterns and risk of dementia in older adults: The ARIC Neurocognitive Study.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
introductionMeasuring day-to-day sleep variability might reveal unstable sleep-wake cycles reflecting neurodegenerative processes. We evaluated the association between Alzheimer's disease (AD) fluid biomarkers with day-to-day sleep variability.
methodsIn the PREVENT-AD cohort, 203 dementia-free participants (age: 68.3 ± 5.4; 78 males) with a parental history of sporadic AD were tested with actigraphy and fluid biomarkers. Day-to-day variability (standard deviations over a week) was assessed for sleep midpoint, duration, efficiency, and nighttime activity count.
resultsLower cerebrospinal fluid (CSF) ApoE, higher CSF p-tau181/amyloid-β (Aβ) DISCUSSION: Day-to-day sleep variability were associated with biomarkers of AD in at-risk individuals, suggesting that unstable sleep promotes neurodegeneration or, conversely, that AD neuropathology disrupts sleep-wake cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.