Evidence map›Paper›PMID 38370981›Full record

ArticleMolecular therapy. Nucleic acids2024

Functional requirement of alternative splicing in epithelial-mesenchymal transition of pancreatic circulating tumor.

Lixing Xiao, Haoxiu Sun, Rui Cheng, Rongrong Yang, Xiyun Jin, Zhaochun Xu, Yideng Cai, Yuexin Yang, Fenglan Pang, Guangfu Xue and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lixing XiaoSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Haoxiu SunSchool for Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin 150076, China.
Rui ChengSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Rongrong YangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Xiyun JinSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Zhaochun XuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Yideng CaiSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Yuexin YangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Fenglan PangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Guangfu XueSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Pingping WangSchool for Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin 150076, China.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Huan NieSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Harbin Institute of Technology · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor cells (CTCs) that undergo epithelial-to-mesenchymal transition (EMT) can provide valuable information regarding metastasis and potential therapies. However, current studies on the EMT overlook alternative splicing. Here, we used single-cell full-length transcriptome data and mRNA sequencing of CTCs to identify stage-specific alternative splicing of partial EMT and mesenchymal states during pancreatic cancer metastasis. We classified definitive tumor and normal epithelial cells via genetic aberrations and demonstrated dynamic changes in the epithelial-mesenchymal continuum in both epithelial cancer cells and CTCs. We provide the landscape of alternative splicing in CTCs at different stages of EMT, uncovering cell-type-specific splicing patterns and splicing events in cell surface proteins suitable for therapies. We show that

Indexed as

alternative splicingcirculating tumor cellepithelial-to-mesenchymal transitionMT: Bioinformaticspancreatic ductal adenocarcinoma

Identifiers

PMID38370981
PMCPMC10869908
OpenAlexW4391152202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.