ReviewFrontiers in behavioral neuroscience2024
Neural circuits for the adaptive regulation of fear and extinction memory.
Review in Frontiers in behavioral neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- Human neural stem cell-derived extracellular vesicles improve cognitive function following glioma chemoradiation therapy.Cancer letters · 2026Article
- Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.Psychopharmacology · 2026Article
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular remodeling in the amygdala of older Veterans.Research square · 2026Article
- Locus coeruleus-amygdala circuit disrupts prefrontal control to impair fear extinction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- Excitability-margin narrowing as a candidate gating mechanism for maladaptive circuit reactivation: a ventral CA1-centered model.Frontiers in behavioral neuroscience · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task.Frontiers in behavioral neuroscience · 2026Article
- dCA1 cells encode and update contextual place preference.Frontiers in systems neuroscience · 2026Article
- Filtering the noise: a cerebellar-centered framework for understanding and treating mental illness -a paradigm shift in psychiatry.Frontiers in psychiatry · 2026Article
- Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat.The Journal of comparative neurology · 2025Article
- Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.Molecular psychiatry · 2025Article
- Review
- Article
- Emotional Brain Development: Neurobiological Indicators from Fetus Through Toddlerhood.Brain sciences · 2025Article
- Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans.Communications biology · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Mechanisms of alcohol influence on fear conditioning: A computational model.Alcohol, clinical & experimental research · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The regulation of fear memories is critical for adaptive behaviors and dysregulation of these processes is implicated in trauma- and stress-related disorders. Treatments for these disorders include pharmacological interventions as well as exposure-based therapies, which rely upon extinction learning. Considerable attention has been directed toward elucidating the neural mechanisms underlying fear and extinction learning. In this review, we will discuss historic discoveries and emerging evidence on the neural mechanisms of the adaptive regulation of fear and extinction memories. We will focus on neural circuits regulating the acquisition and extinction of Pavlovian fear conditioning in rodent models, particularly the role of the medial prefrontal cortex and hippocampus in the contextual control of extinguished fear memories. We will also consider new work revealing an important role for the thalamic nucleus reuniens in the modulation of prefrontal-hippocampal interactions in extinction learning and memory. Finally, we will explore the effects of stress on this circuit and the clinical implications of these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.