Evidence map›Paper›PMID 38370832›Full record

ArticlebioRxiv : the preprint server for biology2024

Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.

Taylor N Szyszka, Michael P Andreas, Felicia Lie, Lohra M Miller, Lachlan S R Adamson, Farzad Fatehi, Reidun Twarock, Benjamin E Draper, Martin F Jarrold, Tobias W Giessen and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Taylor N SzyszkaSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-9921-3086
Michael P AndreasDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8871-3053
Felicia LieSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.
Lohra M MillerChemistry Department, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.
Lachlan S R AdamsonSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-9862-9557
Farzad FatehiDepartment of Mathematics, University of York, York, UK.ORCID 0000-0003-3743-5772
Reidun TwarockDepartment of Mathematics, University of York, York, UK.ORCID 0000-0002-1824-2003
Benjamin E DraperMegadalton Solutions Inc., 3750 E Bluebird Ln, Bloomington, IN 47401, USA.
Martin F JarroldChemistry Department, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.ORCID 0000-0001-7084-176X
Tobias W GiessenDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6328-2031
Yu Heng LauSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-6560-8410
The University of Sydney · AUIndiana University Bloomington · USUniversity of Michigan · USUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein capsids are a widespread form of compartmentalisation in nature. Icosahedral symmetry is ubiquitous in capsids derived from spherical viruses, as this geometry maximises the internal volume that can be enclosed within. Despite the strong preference for icosahedral symmetry, we show that simple point mutations in a virus-like capsid can drive the assembly of novel symmetry-reduced structures. Starting with the encapsulin from

Identifiers

PMID38370832
PMCPMC10871247
OpenAlexW4391609784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.