Evidence map›Paper›PMID 38370780›Full record

ArticlebioRxiv : the preprint server for biology2024

PP2A catalytic subunit alpha is critically required for CD8

Xian Zhou, Meilu Li, Minji Ai, Yanfeng Li, Xingxing Zhu, Michael J Hansen, Jun Zhong, Kenneth L Johnson, Roman Zenka, Akhilesh Pandey and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xian ZhouDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Meilu LiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Minji AiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Yanfeng LiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Xingxing ZhuDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Michael J HansenDepartment of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Jun ZhongDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Kenneth L JohnsonProteomics Core, Mayo Clinic, Rochester, MN 55905, USA.
Roman ZenkaProteomics Core, Mayo Clinic, Rochester, MN 55905, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-9943-6127
Larry R PeaseDepartment of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Hu ZengDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-9909-7732
Mayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Context dependent amino acid availability and sensing determines humoral immunityR01AI162678 · NIAID · MAYO CLINIC ROCHESTER · PI Hu Zeng · 2022 to 2026
$2.3M
Immune Checkpoint Inhibition and humoral immune response in systemic autoimmunityR01AR077518 · NIAMS · MAYO CLINIC ROCHESTER · PI ZENG, HU · 2021 to 2025
$1.7M
NCI NIH HHS P30 CA015083NIAID NIH HHS R01 AI162678NIAMS NIH HHS R01 AR077518
6 · The paper itself

Abstract

While the functions of tyrosine phosphatases in T cell biology have been extensively studied, our knowledge on the contribution of serine/threonine phosphatases in T cells remains poor. Protein phosphatase 2A (PP2A) is one of the most abundantly expressed serine/threonine phosphatases. It is important in thymocyte development and CD4

Identifiers

PMID38370780
PMCPMC10871277
OpenAlexW4391694665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.