Evidence map›Paper›PMID 38370765›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Associations between genetically predicted iron status and cardiovascular disease risk: A Mendelian randomization study.

Alexa Barad, Andrew G Clark, Kimberly O O'Brien, Eva K Pressman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexa BaradDivision of Nutritional Sciences, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-3940-362X
Andrew G ClarkDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
Kimberly O O'BrienDivision of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
Eva K PressmanDepartment of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA.
Cornell University · USUniversity of Rochester Medical Center · US

Funding

Ethnic Differences in Iron AbsorptionR01DK122216 · NIDDK · CORNELL UNIVERSITY · PI O'BRIEN, KIMBERLY O · 2019 to 2022
$2.2M
NIDDK NIH HHS R01 DK122216
6 · The paper itself

Abstract

Background: Mendelian randomization (MR) studies suggest a causal effect of iron (Fe) status on cardiovascular disease (CVD) risk, but it is unknown if these associations are confounded by pleiotropic effects of the instrumental variables (IV) on CVD risk factors. We aimed to investigate the effect of Fe status on CVD risk controlling for CVD risk factors. Methods: Fe biomarker IVs (total Fe binding capacity (TIBC, Results: With UVMR analyses, we found higher genetically predicted Fe status to be associated with a greater risk of CES (TSAT: OR 1.17 [95%CI 1.03, 1.33], SI: OR 1.21 [ 95%CI 1.02, 1.44]; TIBC: OR 0.81 [95%CI 0.69, 0.94]). The detrimental effects of Fe status on CES risk remained unaffected when adjusting for CVD risk factors (all Discussion: Higher Fe status was associated with a greater risk of CES independent of CVD risk factors, and this effect was partly mediated by DBP. These findings support a role of Fe status as a modifiable risk factor for CES.

Indexed as

cardioembolic stroke riskiron statusischemic strokeMendelian randomization

Identifiers

PMID38370765
PMCPMC10871385
OpenAlexW4391557827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.