Evidence map›Paper›PMID 38370750›Full record

ArticlebioRxiv : the preprint server for biology2024

Global diversity, recurrent evolution, and recent selection on amylase structural haplotypes in humans.

Davide Bolognini, Alma Halgren, Runyang Nicolas Lou, Alessandro Raveane, Joana L Rocha, Andrea Guarracino, Nicole Soranzo, Jason Chin, Erik Garrison, Peter H Sudmant

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Davide BologniniHuman Technopole, Milan, Italy.
Alma HalgrenDepartment of Integrative Biology, University of California Berkeley, Berkeley, USA.
Runyang Nicolas LouDepartment of Integrative Biology, University of California Berkeley, Berkeley, USA.
Alessandro RaveaneHuman Technopole, Milan, Italy.
Joana L RochaDepartment of Integrative Biology, University of California Berkeley, Berkeley, USA.
Andrea GuarracinoDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, USA.
Nicole SoranzoHuman Technopole, Milan, Italy.
Jason ChinFoundation for Biological Data Science, Belmont, USA.
Erik GarrisonDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, USA.
Peter H SudmantDepartment of Integrative Biology, University of California Berkeley, Berkeley, USA.ORCID 0000-0002-9573-8248
University of California, Berkeley · USHuman Technopole · ITUniversity of Tennessee Health Science Center · USThe Dia Foundation for Research on Ageing Societies · JP

Funding

The evolution and diversity of mutation, molecular fidelity, and genome structureR35GM142916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Peter Heshedahl Sudmant · 2021 to 2026
$2.5M
NIGMS NIH HHS R35 GM142916
6 · The paper itself

Abstract

The adoption of agriculture, first documented ~12,000 years ago in the Fertile Crescent, triggered a rapid shift toward starch-rich diets in human populations. Amylase genes facilitate starch digestion and increased salivary amylase copy number has been observed in some modern human populations with high starch intake, though evidence of recent selection is lacking. Here, using 52 long-read diploid assemblies and short read data from ~5,600 contemporary and ancient humans, we resolve the diversity, evolutionary history, and selective impact of structural variation at the amylase locus. We find that amylase genes have higher copy numbers in populations with agricultural subsistence compared to fishing, hunting, and pastoral groups. We identify 28 distinct amylase structural architectures and demonstrate that nearly identical structures have arisen recurrently on different haplotype backgrounds throughout recent human history.

Identifiers

PMID38370750
PMCPMC10871346
OpenAlexW4391692664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.