Evidence map›Paper›PMID 38370729›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Hyper-diverse antigenic variation and resilience to transmission-reducing intervention in falciparum malaria.

Qi Zhan, Qixin He, Kathryn E Tiedje, Karen P Day, Mercedes Pascual

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Qi ZhanCommittee on Genetics, Genomics and Systems Biology, The University of Chicago; Chicago, IL, 60637, USA.ORCID 0000-0001-7959-817X
Qixin HeDepartment of Biological Sciences, Purdue University; West Lafayette, IN, 47907, USA.
Kathryn E TiedjeDepartment of Microbiology and Immunology, Bio21 Institute and Peter Doherty Institute, The University of Melbourne; Melbourne, Australia.
Karen P DayDepartment of Microbiology and Immunology, Bio21 Institute and Peter Doherty Institute, The University of Melbourne; Melbourne, Australia.ORCID 0000-0002-6115-6135
Mercedes PascualDepartment of Biology, New York University; New York, NY, 10012, USA.
The University of Melbourne · AUPurdue University West Lafayette · USSanta Fe Institute · USUniversity of Chicago · US

Funding

Temporal strain structure and response to interventions in a high endemicity region of Plasmodium falciparum R01AI149779 · NIAID · UNIVERSITY OF CHICAGO · PI DAY, KAREN PATRICIA, KORAM, KWADWO ANSAH · 2019 to 2023
$3.0M
The impact of seasonality and vector control on the population structure of Plasmodium falciparumR01TW009670 · FIC · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAY, KAREN PATRICIA, KORAM, KWADWO ANSAH · 2013 to 2016
$1.8M
FIC NIH HHS R01 TW009670NIAID NIH HHS R01 AI149779
6 · The paper itself

Abstract

Intervention against falciparum malaria in high transmission regions remains challenging, with relaxation of control efforts typically followed by rapid resurgence. Resilience to intervention co-occurs with incomplete immunity, whereby children eventually become protected from severe disease but not infection and a large transmission reservoir results from high asymptomatic prevalence across all ages. Incomplete immunity relates to the vast antigenic variation of the parasite, with the major surface antigen of the blood stage of infection encoded by the multigene family known as

Identifiers

PMID38370729
PMCPMC10871444
OpenAlexW4391542859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.