Evidence map›Paper›PMID 38370689›Full record

ArticlebioRxiv : the preprint server for biology2024

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.

Verena Haage, John F Tuddenham, Natacha Comandante-Lou, Alex Bautista, Anna Monzel, Rebecca Chiu, Masashi Fujita, Frankie G Garcia, Prabesh Bhattarai, Ronak Patel and 21 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 16 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 5 institutions in 2 countries.

Verena Haage *Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0001-7569-8421
John F Tuddenham *Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-0186-2652
Natacha Comandante-Lou *Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-7981-7333
Alex BautistaCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0003-4218-7953
Anna MonzelDepartment of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.ORCID 0000-0001-8687-6019
Rebecca ChiuCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.
Masashi FujitaCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-1457-6233
Frankie G GarciaCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-1959-4449
Prabesh BhattaraiDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0003-2991-5514
Ronak PatelDepartment of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0001-6782-6470
Alice BuonfiglioliDepartment of Psychiatry, Icahn School of Medicine, 1460 Madison Avenue, New York, NY, 10029, United States.ORCID 0000-0002-5550-9360
Juan IdiarteDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.
Mathieu HermanDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.
Alison RinderspacherDepartment of Medicine, Columbia University, New York, NY 10032, United States.ORCID 0000-0001-6840-8422
Angeliki MelaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-0099-9267
Wenting ZhaoDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, United States.
Michael G ArgenzianoDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-3374-9037
Julia L FurnariDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Matei A BanuDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-2330-1810
Donald W LandryDepartment of Medicine, Columbia University, New York, NY 10032, United States.
Jeffrey N BruceDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6844-0286
Peter CanollDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-7001-0226
Ya ZhangCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.
Tal NurielDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-5252-8048
Caghan KizilDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-8164-9762
Andrew A SproulDepartment of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0001-6972-1592
Lotje D de WitteDepartment of Psychiatry, Icahn School of Medicine, 1460 Madison Avenue, New York, NY, 10029, United States.ORCID 0000-0002-7235-9958
Peter A SimsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-3921-4837
Vilas MenonCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-4096-8601
Martin PicardDepartment of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.ORCID 0000-0003-2835-0478
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-8057-2505
Columbia University Irving Medical Center · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SKColumbia University · USIcahn School of Medicine at Mount Sinai · USNew York State Psychiatric Institute

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Discovery and validation of genetic variants affecting microglial activation in Alzheimer's diseaseRF1AG070438 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L · 2020 to 2020
$6.2M
Deconstructing and modeling the single cell architecture of the Alzheimer brainRF1AG057473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2017 to 2018
$4.0M
Identifying, validating and targeting AD susceptibility networks in monocytesR01AG048015 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L · 2014 to 2018
$1.9M
Discovery and validation of genetic variants affecting microglial activation in Alzheimer's diseaseR01AG070438 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L · 2024 to 2024
$1.6M
Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.F30CA261090 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TUDDENHAM, JOHN · 2021 to 2023
$155k
NCI NIH HHS F30 CA261090NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG070438NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG070438NIA NIH HHS U01 AG061356NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

While efforts to identify microglial subtypes have recently accelerated, the relation of transcriptomically defined states to function has been largely limited to

Identifiers

PMID38370689
PMCPMC10871172
OpenAlexW4391708371

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.